Comparative Analysis of Clinical and Imaging Features of Osteomalacia and Spondyloarthritis.

Frontiers in Medicine
Zheng ZhaoFeng Huang

Abstract

Aim: To compare the clinical and radiological characteristics of osteomalacia and spondyloarthritis/ankylosing spondylitis (SpA/AS) in order to provide a basis for differential diagnosis. Methods: We carried out a retrospective analysis of patients who were diagnosed with osteomalacia at the First Medical Center of 301 Hospital (Beijing, China) from January 2012 to January 2019. The clinical and radiological data of all patients were collected; at the same time, we selected age- and gender-matched patients with SpA/AS for comparison. Results: We enrolled a total of 76 patients, 38 with osteomalacia, and 38 with SpA/AS. The mean ages of the two groups were, respectively 44.62 ± 14.90 years and 44.85 ± 9.76 years (P > 0.05). Of patients with osteomalacia, 65.79% (n = 25) had previously been misdiagnosed with SpA/AS. In the osteomalacia and SpA/AS groups, there were, respectively 31 and 33 patients with low back pain, 22 and 13 patients with peripheral arthralgia, and 13 and 3 patients with heel pain. Alkaline phosphatase (ALP) level was significantly higher in the osteomalacia than in the SpA/AS group (P < 0.05). Serum phosphorus levels, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, and bone mineral densi...Continue Reading

References

May 5, 2004·Best Practice & Research. Clinical Rheumatology·Antonio J Reginato, Juliet Arambulo Coquia
Jun 24, 2009·Trends in Endocrinology and Metabolism : TEM·Seiji Fukumoto, T John Martin
Dec 12, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Ann Prentice

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