Comparative analysis of cortical layering and supragranular layer enlargement in rodent carnivore and primate species

Brain Research
Jeffrey HutslerKristin K Porter


The mammalian cerebral cortex is composed of individual layers characterized by the cell types they contain and their afferent and efferent connections. The current study examined the raw, and size-normalized, laminar thicknesses in three cortical regions (somatosensory, motor, and premotor) of fourteen species from three orders of mammals: primates, carnivores, and rodents. The proportional size of the pyramidal cell layers (supra- and infragranular) varied between orders but was similar within orders despite wide variance in absolute cortical thickness. Further, supragranular layer thickness was largest in primates (46 +/- 3 percent), followed by carnivores (36 +/- 3 percent), and then rodents (19 +/- 4 percent), suggesting a distinct difference in the proportion of cortex devoted to corticocortical connectivity across these orders. Although measures of supragranular layer thickness are highly correlated with measures of overall brain size, such associations are not present when independent contrasts are used to control for phylogenetic inertia. Interestingly, neurogenesis time span remains strongly associated with supragranular layer thickness despite size normalization and controlling for phylogenetic inertia. Such layering...Continue Reading


Jun 25, 2003·Brain and Language·Padraic Monaghan, Richard Shillcock
Sep 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Thomas PetermannDietmar Plenz
Aug 24, 2011·Brain, Behavior and Evolution·Christine J CharvetBarbara L Finlay
Feb 13, 2016·Current Opinion in Neurobiology·Kenneth D Miller
Jan 8, 2016·Proceedings of the National Academy of Sciences of the United States of America·Fenna M KrienenChet C Sherwood
Aug 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Fernando García-Moreno, Zoltán Molnár
Aug 12, 2009·Methods : a Companion to Methods in Enzymology·Peter Kochunov, Michael Duff Davis
Aug 28, 2007·Brain Research Bulletin·David Neill
Sep 21, 2011·The European Journal of Neuroscience·Christine J Charvet, Georg F Striedter
Jun 25, 2010·The Journal of Comparative Neurology·Joanna J RowellClifton W Ragsdale
Jul 28, 2012·Evolution; International Journal of Organic Evolution·Eric LewitusChet C Sherwood
Jan 15, 2014·The Journal of Comparative Neurology·Adele M H SeelkeLeah A Krubitzer
Aug 19, 2015·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Mayuko InoueKen-Ichi Mizutani
Oct 5, 2006·Seminars in Fetal & Neonatal Medicine·Sampsa Vanhatalo, Kai Kaila
Apr 22, 2015·Journal of Pharmacological and Toxicological Methods·Monica MeteaJoseph Arezzo
Feb 5, 2014·Current Opinion in Neurobiology·Matthias Kaschube
Nov 26, 2014·Proceedings of the National Academy of Sciences of the United States of America·Diarmuid J CahalaneBarbara L Finlay
Aug 21, 2013·Cerebral Cortex·Christine J CharvetBarbara L Finlay
Jan 28, 2015·Nature Neuroscience·Kenneth D Harris, Gordon M G Shepherd
Apr 6, 2018·Annual Review of Neuroscience·Kenneth S Kosik, Tomasz Nowakowski
Feb 3, 2018·Scientific Reports·Milan HalgrenEric Halgren
Oct 26, 2018·Cerebral Cortex·Nafiseh AtapourMarcello G P Rosa
Jul 28, 2012·The Journal of Trauma and Acute Care Surgery·Karin A RafaelsAmanda Toman
Jan 11, 2020·Frontiers in Cellular Neuroscience·Kanella Prodromidou, Rebecca Matsas
Dec 6, 2016·Frontiers in Psychology·Stewart Shipp
Jul 19, 2020·Integrative and Comparative Biology·Yuxiang Liu, Genevieve Konopka
Nov 13, 2020·Frontiers in Cell and Developmental Biology·Veronique CortayColette Dehay


Jun 20, 1991·Nature·P H Harvey, A Purvis
Jan 1, 1989·Progress in Neurobiology·M A Hofman
Aug 1, 1986·The International Journal of Neuroscience·T Sawaguchi, K Kubota
Jul 8, 1988·Science·Pasko Rakic
Nov 1, 1967·Journal of Psychosomatic Research·T J Luparello
Jun 1, 1980·Brain : a Journal of Neurology·A J RockelT P Powell
Jan 1, 1980·Nursing Administration Quarterly·L Braak, M Cate
Jan 1, 1981·Brain, Behavior and Evolution·G S Doetsch, A L Towe
Jun 29, 1995·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Purvis
Jun 1, 1995·Computer Applications in the Biosciences : CABIOS·A Purvis, A Rambaut
Jun 16, 1995·Science·Barbara L Finlay, R B Darlington
Apr 19, 1996·Neuroscience Letters·T S SkoglundC H Berthold
Apr 1, 1997·Brain : a Journal of Neurology·V B Mountcastle
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·D R Kornack, Pasko Rakic
Mar 14, 1998·Trends in Neurosciences·M Marín-Padilla
Jul 22, 1999·The Journal of Comparative Neurology·R B DarlingtonBarbara L Finlay
Sep 25, 1999·Cerebral Cortex·J L Rubenstein, Pasko Rakic
Apr 20, 2000·Journal of Neuroscience Methods·Daniel P BuxhoevedenManuel F Casanova
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·E G Jones
Sep 6, 2000·Brain, Behavior and Evolution·Todd M Preuss
Jul 27, 2001·American Journal of Physical Anthropology·Daniel P BuxhoevedenManuel F Casanova
Aug 3, 2001·Neuroscience·B ClancyBarbara L Finlay
Feb 2, 2002·Nature Reviews. Neuroscience·Pasko Rakic
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Simon M Reader, Kevin N Laland
Apr 19, 2002·Brain : a Journal of Neurology·Daniel P Buxhoeveden, Manuel F Casanova
Jan 22, 2003·Nature Neuroscience·Daniel L Adams, Jonathan C Horton
Aug 6, 2003·Trends in Neurosciences·Jeffrey Hutsler, Ralf A W Galuske
Feb 10, 1951·Journal of the American Medical Association·P BAILEY, F A GIBBS

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