Comparative Analysis of Diffusional Kurtosis Imaging, Diffusion Tensor Imaging, and Diffusion-Weighted Imaging in Grading and Assessing Cellular Proliferation of Meningiomas

AJNR. American Journal of Neuroradiology
L LinH Lin

Abstract

An accurate evaluation of the World Health Organization grade and cellular proliferation is particularly important in meningiomas. Our aim was to prospectively evaluate and compare diffusional kurtosis imaging, DTI, and DWI metrics in determining the grade and cellular proliferation of meningiomas. Ninety-six consecutive patients with histopathologically confirmed meningiomas were included in this study. Mean kurtosis, radial kurtosis, axial kurtosis, fractional anisotropy, mean diffusivity, and ADC were semiautomatically obtained in the solid components of tumors. Each normalized diffusion value was compared between high-grade meningiomas and low-grade meningiomas using the Mann-Whitney U test. Receiver operating characteristic, multiple logistic regression, and Pearson correlation analysis were used for statistical evaluations. Diffusional kurtosis imaging metrics (mean kurtosis, radial kurtosis, and axial kurtosis) were significantly higher in high-grade meningiomas than in low-grade meningiomas (P ≤ .001). Mean diffusivity and ADC were significantly lower in high-grade meningiomas than in low-grade meningiomas (P = .003 and .002). Mean kurtosis had significantly greater area the under curve values than mean diffusivity and ...Continue Reading

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Citations

Jan 29, 2019·Neurologia Medico-chirurgica·Satoshi NakasuKen-Ichi Matsumura
Feb 16, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Wei YueJingliang Cheng
Jan 14, 2021·Scientific Reports·Hyeong-Cheol OhHun Ho Park
Oct 16, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tianjia ZhuHao Huang
May 29, 2019·Journal of Neuroradiology. Journal De Neuroradiologie·Shun ZhangIlhami Kovanlikaya
Aug 6, 2021·Frontiers in Human Neuroscience·Rafael Neto HenriquesAriel Rokem

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