Abstract
Significant insights into the biology of Plasmodium vivax have been gained from the ability to successfully adapt human infections to non-human primates. P. vivax strains grown in monkeys serve as a renewable source of parasites for in vitro and ex vivo experimental studies and functional assays, or for studying in vivo the relapse characteristics, mosquito species compatibilities, drug susceptibility profiles or immune responses towards potential vaccine candidates. Despite the importance of these studies, little is known as to how adaptation to a different host species may influence the genome of P. vivax. In addition, it is unclear whether these monkey-adapted strains consist of a single clonal population of parasites or if they retain the multiclonal complexity commonly observed in field isolates. Here we compare the genome sequences of seven P. vivax strains adapted to New World monkeys with those of six human clinical isolates collected directly in the field. We show that the adaptation of P. vivax parasites to monkey hosts, and their subsequent propagation, did not result in significant modifications of their genome sequence and that these monkey-adapted strains recapitulate the genomic diversity of field isolates. Our a...Continue Reading
References
Jul 6, 1986·Nature·L G Pologe, J V Ravetch
Jan 17, 1986·Cell·L M CorcoranD J Kemp
Aug 26, 1966·Science·M D YoungC M Johnson
Jan 10, 2002·The Journal of Parasitology·J S SullivanW E Collins
Dec 3, 2003·Trends in Parasitology·V Ann Stewart
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Janet Cox-SinghBalbir Singh
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N J White
Oct 10, 2008·Nature·Jane M CarltonClaire M Fraser-Liggett
Oct 10, 2008·Nature·A PainM Berriman
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Neekesh V DhariaElizabeth A Winzeler
Dec 15, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Cara N Henry-HalldinPeter A Zimmerman
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
Aug 7, 2012·Nature Genetics·Daniel E NeafseyJane M Carlton
Aug 7, 2012·Nature Genetics·Shin-Ichiro TachibanaKazuyuki Tanabe
Sep 13, 2012·PLoS Neglected Tropical Diseases·Ernest R ChanDavid Serre
Sep 13, 2012·PLoS Neglected Tropical Diseases·Peter W GethingSimon I Hay
Jan 12, 2013·PloS One·Sarah AuburnRic N Price
Feb 15, 2013·PLoS Genetics·Selina E R BoppElizabeth A Winzeler
Apr 19, 2013·Lancet·Chris CotterRichard G A Feachem
Nov 28, 2013·PLoS Neglected Tropical Diseases·Didier MenardPeter A Zimmerman
Dec 18, 2013·PLoS Neglected Tropical Diseases·James HesterDavid Serre
Feb 22, 2014·Nature Communications·Weimin LiuPaul M Sharp
Feb 26, 2014·Malaria Journal·Thuy H TaJosé M Rubio
Jun 6, 2014·PLoS Neglected Tropical Diseases·Andrew Taylor BrightElizabeth A Winzeler
Citations
Mar 17, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Patrick L SuttonSteven A Sullivan
Nov 10, 2015·Scientific Reports·Juan P IsazaJuan F Alzate
Feb 24, 2018·Frontiers in Cellular and Infection Microbiology·Catarina BourgardFabio T M Costa
Jan 25, 2018·MBio·Jean PopoviciDavid Serre
Aug 25, 2018·PLoS Biology·Aude GilabertVirginie Rougeron
Jun 4, 2019·PLoS Neglected Tropical Diseases·Lisa H VerzierJulian C Rayner
Dec 29, 2015·PLoS Neglected Tropical Diseases·David J WinterAnanias A Escalante
Feb 23, 2020·Expert Review of Vaccines·Manuel Alfonso PatarroyoDarwin A Moreno-Pérez
May 17, 2019·MSphere·Miriam T GeorgeJohn H Adams
Nov 25, 2016·The Journal of Biological Chemistry·Sumit RathoreYagya D Sharma
Aug 2, 2019·Clinical Microbiology Reviews·Xin-Zhuan SuThomas E Wellems
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Xin-Zhuan SuDeirdre A Joy
Nov 21, 2017·Trends in Parasitology·Jennifer S Armistead, John H Adams
Sep 23, 2021·FEMS Microbiology Reviews·Virginie RougeronFranck Prugnolle