PMID: 11324749Apr 28, 2001Paper

Comparative analysis of G1 glycoprotein-coding sequences of Cache Valley virus (Bunyaviridae: Bunyavirus) isolates

Virus Genes
C L Brockus, P R Grimstad

Abstract

The complete 4463 nucleotide sequence for the medium segment viral RNA of Cache Valley virus has been cloned and sequenced in four isolates; in addition, the G1 glycoprotein extracellular coding domains are completed for nine additional isolates, including two subtypes, Ft. Sherman (86MSP18) and Tlacotalpan (61D240) viruses. The 13 represent isolations spanning over 45 years and a large geographic area, including the U.S., Mexico, Canada, and Panama. Glycosylation sites in G1 are generally conserved among all except the Ft. Davis, Panama (90P686) isolate, which loses a site otherwise conserved within the serogroup. Comparison of the G1 coding regions indicates a number of shared amino acid substitutions within a centrally located 70 amino acid hypervariable domain, which seems to fall outside the primary antigenic domains of G1, most of which are found within the amino half of the protein, while a less antigenic region is predicted for the carboxyl half of the protein encoded beyond the hypervariable domain. Numerous amino acid substitutions are found within various antigenic regions, which may be an indication of altered neutralization or hemagglutination sites. Putative phosphorylation sites are indicated, most of which are w...Continue Reading

Citations

Jan 27, 2012·The Journal of General Virology·Rashmi ChowdharyThomas Briese
Sep 19, 2003·The Journal of General Virology·J C OsborneS T Nichol
Sep 28, 2004·The Journal of General Virology·Thomas BrieseW Ian Lipkin

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