Comparative analysis of gene expression in maternal peripheral blood and monocytes during spontaneous preterm labor

American Journal of Obstetrics and Gynecology
Alison G PaquetteGlobal Alliance to Prevent Prematurity and Stillbirth Systems Biology of Preterm Birth Team

Abstract

Preterm birth is the leading cause of newborn death worldwide, and is associated with significant cognitive and physiological challenges in later life. There is a pressing need to define the mechanisms that initiate spontaneous preterm labor, and for development of novel clinical biomarkers to identify high-risk pregnancies. Most preterm birth studies utilize fetal tissues, and there is limited understanding of the transcriptional changes that occur in mothers undergoing spontaneous preterm labor. Earlier work revealed that a specific population of maternal peripheral leukocytes (macrophages/monocytes) play an active role in the initiation of labor. Thus, we hypothesized that there are dynamic gene expression changes in maternal blood leukocytes during preterm labor. Using next-generation sequencing we aim to characterize the transcriptome in whole blood leukocytes and peripheral monocytes of women undergoing spontaneous preterm labor compared to healthy pregnant women who subsequently delivered at full term. RNA sequencing was performed in both whole blood and peripheral monocytes from women who underwent preterm labor (24-34 weeks of gestation, N = 20) matched for gestational age to healthy pregnant controls (N = 30). All par...Continue Reading

Citations

Feb 16, 2019·American Journal of Reproductive Immunology : AJRI·Yaozhu LengNardhy Gomez-Lopez
Jul 26, 2019·Journal of Cellular and Molecular Medicine·Alison G PaquetteStephen J Lye
Sep 22, 2018·The Journal of Clinical Endocrinology and Metabolism·Jennifer Y HsuMary E Sabatini
Apr 21, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Alba Farràs LlobetElena Carreras
Jan 11, 2020·Frontiers in Immunology·Nardhy Gomez-LopezAdi L Tarca
Dec 10, 2020·Computational and Structural Biotechnology Journal·Lingyu Li, Zhi-Ping Liu
Sep 9, 2019·Journal of Perinatal Medicine·Nardhy Gomez-LopezChaur-Dong Hsu
Jan 2, 2021·The Journal of Pharmacology and Experimental Therapeutics·Scott D BarnettIain L O Buxton
Feb 7, 2020·American Journal of Obstetrics and Gynecology·Agustin Conde-AgudeloKypros H Nicolaides
Dec 18, 2021·American Journal of Obstetrics and Gynecology·Hai JiangYangyu Zhao

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