Comparative Analysis of Genome Diversity in Bullmastiff Dogs

PloS One
Sally-Anne MortlockPeter Williamson

Abstract

Management and preservation of genomic diversity in dog breeds is a major objective for maintaining health. The present study was undertaken to characterise genomic diversity in Bullmastiff dogs using both genealogical and molecular analysis. Genealogical analysis of diversity was conducted using a database consisting of 16,378 Bullmastiff pedigrees from year 1980 to 2013. Additionally, a total of 188 Bullmastiff dogs were genotyped using the 170,000 SNP Illumina CanineHD Beadchip. Genealogical parameters revealed a mean inbreeding coefficient of 0.047; 142 total founders (f); an effective number of founders (fe) of 79; an effective number of ancestors (fa) of 62; and an effective population size of the reference population of 41. Genetic diversity and the degree of genome-wide homogeneity within the breed were also investigated using molecular data. Multiple-locus heterozygosity (MLH) was equal to 0.206; runs of homozygosity (ROH) as proportion of the genome, averaged 16.44%; effective population size was 29.1, with an average inbreeding coefficient of 0.035, all estimated using SNP Data. Fine-scale population structure was analysed using NETVIEW, a population analysis pipeline. Visualisation of the high definition network cap...Continue Reading

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Citations

Jun 30, 2018·PloS One·Jaakko L O PohjoismäkiHeidi Anderson
Aug 27, 2019·PloS One·Silvie NeradilováBarbora Černá Bolfíková
Mar 14, 2018·Ecology and Evolution·Andrea TalentiPaola Crepaldi
Feb 18, 2016·Bioinformatics and Biology Insights·Sally-Anne MortlockPeter Williamson
Feb 23, 2019·Animal Genetics·S-A MortlockM S Khatkar
Aug 7, 2019·BMC Genetics·Chandima GajaweeraSeung Hwan Lee
Mar 21, 2020·Animals : an Open Access Journal From MDPI·Antonio BoccardoMaria Giuseppina Strillacci
Aug 23, 2020·Animals : an Open Access Journal From MDPI·Karolína MachováEmil Krupa
Oct 22, 2020·Animals : an Open Access Journal From MDPI·Arianna BiondaPaola Crepaldi
Nov 4, 2020·Animals : an Open Access Journal From MDPI·Ivona Djurkin KušecGoran Kušec
Mar 20, 2021·Scientific Reports·Pamela Xing Yi SohPeter Williamson

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Methods Mentioned

BETA
genotyping
chip

Software Mentioned

pedigree
PEDIG
NeEstimator
Cytoscape
intgen
Plink
NETVIEW
ngen
SPC
ENDOG

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