Comparative analysis of hepatitis B virus genotype a molecular evolution in patients infected with HBV and in patients co-infected with HBV and HIV

Journal of Medical Virology
L CassinoJ Quarleri

Abstract

HIV infection has a significant impact on the natural progression of liver disease caused by infection with hepatitis B virus (HBV), but its role in the molecular evolution of HBV is unknown. It is difficult to study the molecular evolution of HBV longitudinally considering its genomic complexity, which implies the analysis of paired samples. This study aimed to analyze the difference in the evolutionary dynamics of HBV among patients with HIV and uninfected individuals. In this study, 17 patients infected chronically with HBV were recruited, 9 of them were co-infected with HIV. Patients were HBe antigen-positive and infected with HBV genotype A. Paired plasma samples were collected from each patient 3 years apart, and they were compared subsequently to each other. The HBV phylogenetic inference among isolates from patients infected with HBV and co-infected with HBV and HIV tends to cluster separately. Likewise, when comparing the HBV evolutionary rate and genetic distances, values were higher in the former in both preC/C and S genomic regions. Intra-host analyses of HBV isolates revealed high diversity and complexity of quasispecies among patients infected with HBV exhibiting high numbers of viral variants and genetic distance...Continue Reading

References

Jan 27, 1999·Bioinformatics·D Posada, K A Crandall
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H L ChanA S Lok
Mar 21, 2001·The Journal of General Virology·P Simmonds
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chi-Jen Chu, Anna S F Lok
Dec 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hajime SumiHiromitsu Saisho
Sep 19, 2003·AIDS Research and Human Retroviruses·Mayte Pérez-OlmedaVincent Soriano
Oct 29, 2004·Bioinformatics·Sergei L Kosakovsky PondSpencer V Muse
Feb 11, 2005·Molecular Biology and Evolution·Sergei L Kosakovsky Pond, Simon D W Frost
Oct 17, 2006·Journal of Virology·Carla OsiowyGerald Y Minuk
Dec 5, 2006·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Kristi M Westover, Austin L Hughes
Apr 25, 2007·Virology·Chiara De MaddalenaGianguglielmo Zehender
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Aug 9, 2007·Journal of Molecular Evolution·Yang Zhou, Edward C Holmes
Sep 15, 2007·Gastroenterology·Seng Gee LimAllen Gerard Rodrigo
Nov 13, 2007·BMC Evolutionary Biology·Alexei J Drummond, Andrew Rambaut
Oct 6, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Lucila CassinoJorge Quarleri
Nov 6, 2009·Antiviral Research·Vincent SorianoPablo Barreiro
Dec 17, 2009·Journal of Viral Hepatitis·S M JazayeriW F Carman
Jan 22, 2010·Journal of Virology·Hurng-Yi WangDing-Shinn Chen
Feb 17, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Fuat KurbanovMasashi Mizokami
Jun 16, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S C PezzanoV A Mbayed
Jul 27, 2010·Virology·Jennifer AudsleyPeter A Revill

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.