Abstract
Cyclin-dependent kinase inhibitors are a growing family of molecules that regulate important transitions in the cell cycle. At least one of these molecules, p16, has been implicated in human tumorigenesis while its close homolog, p15, is induced by cell contact and transforming growth factor-beta (TGF-beta). To investigate the evolutionary and functional features of p15 and p16, we have isolated mouse (Mus musculus) homologs of each gene. Comparative analysis of these sequences provides evidence that the genes have similar functions in mouse and human. In addition, the comparison suggests that a gene conversion event is part of the evolution of the human p15 and p16 genes.
Citations
Apr 12, 2002·Cancer Genetics and Cytogenetics·Yong-Bum ParkJun Yokota
Jan 20, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y W LinJ C Sheu
Apr 8, 2004·DNA and Cell Biology·Anne Di TommasoVéronique Ladeveze
Dec 5, 1998·DNA and Cell Biology·T E SherburnR D Ley
Sep 2, 1998·The EMBO Journal·F J StottG Peters
Mar 12, 2008·Cancer Letters·P KanellouD A Spandidos
Dec 6, 2005·Hematology/oncology Clinics of North America·Evan Pisick, Ravi Salgia
Jun 2, 2006·Biochimie·D SarrouilheV Ladeveze
Mar 21, 2009·The British Journal of Dermatology·P KanellouD A Spandidos
Nov 10, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Steven KazianisRonald B Walter
Dec 23, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Shinsuke OhtaYoshinobu Kubota
Jun 23, 2004·Biochemical and Biophysical Research Communications·Min KimKenneth Cowan
Jul 8, 1999·The American Journal of Pathology·I OrlowC Cordon-Cardo
Nov 21, 2009·JACC. Cardiovascular Interventions·Petra HoppmannWerner Koch
May 6, 2006·Pathology, Research and Practice·Minjin LeeHeasoo Koo
Sep 22, 1999·Oncogene·S KazianisR S Nairn
Feb 19, 1998·Environmental Health Perspectives·R Neta
Apr 7, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anne EarlyJohn F X Diffley
Oct 3, 2001·ILAR Journal·R B Walter, S Kazianis
Nov 13, 2001·Oncogene·J Gilley, M Fried
Nov 21, 1998·Biochimica Et Biophysica Acta·M Ruas, G Peters