Abstract
Iron dependent regulator, IdeR, regulates the expression of genes in response to intracellular iron levels in M. tuberculosis. Orthologs of IdeR are present in all the sequenced genomes of mycobacteria. We have used a computational approach to identify conserved IdeR regulated genes across the mycobacteria and the genes that are specific to each of the mycobacteria. Novel iron regulated genes that code for a predicted 4-hydroxy benzoyl coA hydrolase (Rv1847) and a protease dependent antibiotic regulatory system (Rv1846c, Rv0185c) are conserved across the mycobacteria. Although Mycobacterium natural-resistance-associated macrophage protein (Mramp) is present in all mycobacteria, it is, as predicted, an iron-regulated gene in only one species, M. avium subsp. paratuberculosis. We also observed an additional iron-regulated exochelin biosynthetic operon, which is present only in non-pathogenic Mycobacterium, M. smegmatis.
References
Nov 1, 1995·Infection and Immunity·M P SchmittR K Holmes
Nov 1, 1995·Journal of Bacteriology·K J BeggW D Donachie
Sep 1, 1994·Journal of Bacteriology·J R Butterton, S B Calderwood
Apr 1, 1993·Clinical Microbiology Reviews·C M Litwin, S B Calderwood
Mar 15, 1996·Science·R StearmanA Dancis
Apr 1, 1996·Journal of Bacteriology·R A DanielJ Errington
Aug 1, 1997·Journal of Bacteriology·A Martinez, R Kolter
Nov 30, 1998·Chemistry & Biology·L E QuadriC T Walsh
Sep 8, 1999·The Journal of Experimental Medicine·D AgranoffS Krishna
Mar 9, 2000·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·G M RodriguezI Smith
May 12, 2000·Science·N Ramanan, Y Wang
Dec 26, 2001·Nucleic Acids Research·Jesus M CastagnettoMichael E Pique
Jun 18, 2002·Infection and Immunity·G Marcela RodriguezIssar Smith
Jan 10, 2003·Nucleic Acids Research·Aron Marchler-BauerStephen H Bryant
Sep 2, 2003·Journal of Bacteriology·Cosima PelludatJürgen Heesemann
Dec 13, 2003·Tuberculosis·Colin Ratledge
Jan 23, 2004·The Journal of Biological Chemistry·Sophie HaniqueBernard Joris
Jan 31, 2004·International Journal of Food Microbiology·Wei-Li HoCheng-Chun Chou
Mar 24, 2004·Journal of Structural Biology·Tancred Frickey, Andrei N Lupas
Jun 25, 2004·Nucleic Acids Research·Sailu YellaboinaAkash Ranjan
Aug 24, 2004·The Journal of Biological Chemistry·Mark S WilkeNatalie C J Strynadka
Sep 28, 2004·BMC Microbiology·Sailu YellaboinaAkash Ranjan
Oct 20, 2004·Critical Reviews in Microbiology·James L Smith
Mar 5, 2005·Bioinformatics·Prachee PrakashSeyed E Hasnain
May 24, 2005·Infection and Immunity·Pilar DomenechClifton E Barry
Citations
Aug 9, 2012·The Journal of Antimicrobial Chemotherapy·Rok Kopinc, Ales Lapanje
Oct 19, 2010·Journal of Bacteriology·Christopher M Jones, Michael Niederweis
Dec 5, 2006·Journal of Bacteriology·Thomas J RadosevichJudith R Stabel
Jan 27, 2007·BMC Bioinformatics·Sarita RanjanAkash Ranjan
Aug 24, 2007·BMC Genomics·Vaibhav VindalAkash Ranjan
Jul 20, 2007·Chemical Reviews·Dmitry A Rodionov
Mar 11, 2008·FEBS Letters·Vaibhav VindalAkash Ranjan
Nov 21, 2007·Gene·Yusuf AkhterSeyed E Hasnain
Aug 18, 2009·Microbiology·Harish K JanagamaSrinand Sreevatsan
Feb 5, 2015·BMC Genomics·Rienk A RienksmaMartin Gengenbacher
Dec 8, 2014·BMC Genomics·Elke EckeltRalph Goethe
Jun 30, 2015·BioMed Research International·Nidia Leon-SicairosAdrian Canizalez-Román
Mar 24, 2018·Scientific Reports·P V Parvati Sai ArunSailu Yellaboina
Aug 8, 2019·Scientific Reports·Marte S DragsetMagnus Steigedal
Jun 4, 2021·Microbiology·Agnese Serafini
Jun 3, 2021·Cells·Anna BrzostekJarosław Dziadek