PMID: 9555552Apr 29, 1998Paper

Comparative analysis of MiB1 and p53 expression in human bladder tumors and their correlation with cancer progression

European Urology
C PfisterO Bouchot

Abstract

Expression of p53 and MiB1, markers of tumor proliferation, was evaluated in human bladder tumors, and correlated with ploidy and cancer progression in 83 consecutive patients. Transurethral resection of a newly diagnosed bladder tumor was performed in 73 cases, and systematic bladder biopsies were performed in 10 cases after bacillus Calmette-Guerin (BCG) treatment. p53 and MiB1 expression were performed by an immunohistochemical technique and the ploidy was determined on a frozen fragment of the tumor. p53 expression was correlated in relation to grade, stage and combination of grade and stage. MiB1 expression was correlated with cytological grade, and a significant difference was demonstrated between pT0 and pTa, pTa, and pT1, pTa and pT2 tumors but not between pT1 and > or = pT2 tumors. A discordance was observed for the comparison of p53 and MiB1 values, stage by stage, suggesting that these two techniques are independent of each other. A larger proportion of aneuploid tumors were positive for p53 and MiB1 (64.8 vs. 86.5%, respectively), but p53 and MiB1 immunostaining were not better indicators than ploidy alone to predict cancer progression.

Citations

Apr 4, 2003·International Journal of Cancer. Journal International Du Cancer·Lúcio SantosCarlos Lopes
Oct 23, 2019·Human Genomics·Qingqing LiYijia Zhang
Dec 1, 1999·Current Opinion in Urology·H G van der Poel
Feb 1, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L L SantosC S Lopes
Mar 4, 2000·The Urologic Clinics of North America·A R Zlotta, C C Schulman

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