Comparative analysis of mitochondrial fragments transferred to the nucleus in vertebrate

Journal of Genetics and Genomics = Yi Chuan Xue Bao
Hongying QuQingwei Li

Abstract

Mitochondrial DNA sequences transferred to the nucleus give rise to the socalled nuclear mitochondrial DNA (numt). In the GenBank database, 244 numts have been found in six orders of birds (Anseriformes, Columbiformes, Falconiformes, Charadriiformes, Galliformes and Passeriformes). Sequences alignment (NCBI-BLASTN) was carried out with mitochondrial and corresponding nuclear genome sequences in nine vertebrate species. The sequences with high homology were considered as numts. The number of numts ranged from 15 in chicken to 159 in chimpanzee. The sequences of numts in macaque, chimpanzee, and human spanned 100% of the entire mammalian mitochondrial genome. The reconstructed frequency of the mitochondrial gene transferred to the nucleus demonstrated that the rRNA genes had high frequencies than other mitochondrial genes. Using the RepeatMasker program, the transposable elements were detected in the flanking regions of each numt. The results showed that less than 5% of the flanking sequences were made up of repetitive elements in chicken. The GC content of 5'- and 3'-flanking regions of numts in nine species was less than 44%. The analysis of the flanking sequences provided a valuable understanding for future study on mechanism ...Continue Reading

References

Feb 1, 1996·Current Biology : CB·N T Perna, T D Kocher
Mar 1, 1997·Molecular Biology and Evolution·J V LopezS J O'Brien
Feb 5, 1998·Genome Génome / Conseil National De Recherches Canada·G G Vendramin, B Ziegenhagen
Jun 6, 1998·Molecular Biology and Evolution·M A AyliffeJ N Timmis
Mar 27, 1999·Journal of Molecular Evolution·J A DeWoodyR J Baker
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·J D PalmerK Song
Dec 29, 2000·Nature·UNKNOWN Arabidopsis Genome Initiative
Feb 13, 2001·Bioinformatics·J A BedellW Gish
May 23, 2001·Trends in Ecology & Evolution·D BensassonG M. Hewitt
Jun 5, 2002·Genome Research·Markus Woischnik, Carlos T Moraes
Jun 25, 2002·Genomics·Yves TourmenPascal Reynier
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Keith L AdamsJeffrey D Palmer
Mar 12, 2004·Molecular Biology and Evolution·Erik Richly, Dario Leister
Jul 16, 2004·Molecular Biology and Evolution·Erik Richly, Dario Leister
Sep 14, 2004·PLoS Biology·Miria RicchettiBernard Dujon
Mar 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·H G du Buy, F L Riley
Jul 31, 2007·The Journal of Heredity·Agostinho AntunesWarren E Johnson

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Citations

May 14, 2010·Rejuvenation Research·Khachik K MuradianVadim E Fraifeld
Jul 5, 2012·Nucleic Acids Research·Junko TsujiPaul Horton
Jul 9, 2010·Molekuliarnaia biologiia·A I Gaziev, G O Shaĭkhaev
Nov 26, 2010·Animal Genetics·S G NergadzeE Giulotto
Jun 18, 2019·Briefings in Bioinformatics·Dan WangXingbo Zhao
Mar 23, 2018·Journal of Molecular Evolution·Rex Meade Strange, Kimberly J Delaney

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