Comparative analysis of multiple inducible phages from Mannheimia haemolytica

BMC Microbiology
Yan D NiuTim A McAllister

Abstract

Mannheimia haemolytica is a commensal bacterium that resides in the upper respiratory tract of cattle that can play a role in bovine respiratory disease. Prophages are common in the M. haemolytica genome and contribute significantly to host diversity. The objective of this research was to undertake comparative genomic analysis of phages induced from strains of M. haemolytica serotype A1 (535A and 2256A), A2 (587A and 1127A) and A6 (1152A and 3927A). Overall, four P2-like (535AP1, 587AP1, 1127AP1 and 2256AP1; genomes: 34.9-35.7 kb; G+C content: 41.5-42.1 %; genes: 51-53 coding sequences, CDSs), four λ-like (535AP2, 587AP2, 1152AP2 and 3927AP1; genomes: 48.6-52.1 kb; 41.1-41.4 % mol G+C; genes: 77-83 CDSs and 2 tRNAs) and one Mu-like (3927AP2; genome: 33.8 kb; 43.1 % mol G+C; encoding 50 CDSs) phages were identified. All P2-like phages are collinear with the temperate phage φMhaA1-PHL101 with 535AP1, 2256AP1 and 1152AP1 being most closely related, followed by 587AP1 and 1127AP1. Lambdoid phages are not collinear with any other known λ-type phages, with 587AP2 being distinct from 535AP2, 3927AP1 and 1152AP2. All λ-like phages contain genes encoding a toxin-antitoxin (TA) system and cell-associated haemolysin XhlA. The Mu-like phag...Continue Reading

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Citations

Sep 6, 2019·Microbiology and Molecular Biology Reviews : MMBR·Zhong PengBin Wu
Mar 16, 2017·The ISME Journal·Cristina Howard-VaronaMatthew B Sullivan
Mar 10, 2020·International Journal of Genomics·Isabelle Gonçalves de Oliveira PradoDenise Mara Soares Bazzolli
Jun 21, 2018·AMB Express·Renata Urban-ChmielMohammed Mijbas Mohammed Alomari

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Datasets Mentioned

BETA
AASA00000000
ACZX00000000
KP137439

Methods Mentioned

BETA
Assay

Software Mentioned

BLASTP
MAUVE
CoreGenes
CLUSTAL omega
PHAST
BLAST
PSI
GeneOrder4
CLUSTAL
ALIGN

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