Comparative analysis of MVA-CD40L and MVA-TRICOM vectors for enhancing the immunogenicity of chronic lymphocytic leukemia (CLL) cells.

Leukemia Research
Mary T LitzingerClaudia Palena

Abstract

Adenoviral transduction with CD40L and poxviral transduction with B7-1, ICAM-1, and LFA-3 (TRICOM) have been used to enhance the antigen-presenting capacity of chronic lymphocytic leukemia (CLL) cells. This study compares the same vector (modified vaccinia virus strain Ankara (MVA)) encoding CD40L or TRICOM for its ability to enhance the immunogenicity of CLL cells. CLL cells from some patients showed differential responses to each vector in terms of induction of autologous T-cell responses. This study supports the rationale for the use of CLL cells modified ex vivo with pre-specified recombinant MVA vectors as a whole tumor-cell vaccine for immunotherapy in CLL patients.

References

Apr 1, 1993·The Journal of Experimental Medicine·E A Ranheim, T J Kipps
Apr 3, 2003·Journal of the National Cancer Institute·Javier BrionesRonald Levy
Apr 30, 2009·Cancer·Apostolia-Maria Tsimberidou, Michael J Keating
Jun 3, 2009·Nature Reviews. Clinical Oncology·Lisa PleyerRichard Greil

❮ Previous
Next ❯

Citations

May 19, 2012·Seminars in Oncology·David AviganDonald Kufe
Jan 28, 2015·Human Vaccines & Immunotherapeutics·Athalia R PyzerJacalyn Rosenblatt
Mar 29, 2019·International Journal of Molecular Sciences·Tymofiy LutsivHenry J Thompson
Oct 24, 2018·Breast Cancer Research : BCR·Sruthi RavindranathanDavid A Zaharoff

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.