Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia

Journal of Applied Physiology
Anita PawarNanduri R Prabhakar

Abstract

Previous studies suggest that carotid body responses to long-term changes in environmental oxygen differ between neonates and adults. In the present study we tested the hypothesis that the effects of chronic intermittent hypoxia (CIH) on the carotid body differ between neonates and adult rats. Experiments were performed on neonatal (1-10 days) and adult (6-8 wk) males exposed either to CIH (9 episodes/h; 8 h/day) or to normoxia. Sensory activity was recorded from ex vivo carotid bodies. CIH augmented the hypoxic sensory response (HSR) in both groups. The magnitude of CIH-evoked hypoxic sensitization was significantly greater in neonates than in adults. Seventy-two episodes of CIH were sufficient to evoke hypoxic sensitization in neonates, whereas as many as 720 CIH episodes were required in adults, suggesting that neonatal carotid bodies are more sensitive to CIH than adult carotid bodies. CIH-induced hypoxic sensitization was reversed in adult rats after reexposure to 10 days of normoxia, whereas the effects of neonatal CIH persisted into adult life (2 mo). Acute intermittent hypoxia (IH) evoked sensory long-term facilitation of the carotid body activity (sensory LTF, i.e., increased baseline neural activity following acute IH...Continue Reading

References

Sep 1, 1987·American Journal of Obstetrics and Gynecology·R GagnonJ Patrick
Oct 16, 1983·Brain Research·M GrönbladL Rechardt
Jun 1, 1984·The Journal of Physiology·C E BlancoH B McCooke
Jan 26, 1981·Brain Research·B DingerS Fidone
Jan 1, 1994·Biology of the Neonate·C F PoetsD P Southall
Sep 1, 1995·Biological Signals·G E Bisgard
Sep 14, 1999·The American Journal of Physiology·L M SterniJ L Carroll
Jan 22, 2000·Neuroscience Letters·Z Y WangG E Bisgard
Apr 19, 2000·JAMA : the Journal of the American Medical Association·F J NietoT G Pickering
Jun 14, 2000·Journal of Applied Physiology·D F Donnelly
Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·E ShaharJ M Samet
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·David D KlineNanduri R Prabhakar
Dec 18, 2002·Journal of Applied Physiology·John L Carroll
Mar 1, 2003·Acta Physiologica Scandinavica·T KaraV K Somers
Aug 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ying-Jie PengNanduri R Prabhakar
Aug 12, 2003·Journal of Applied Physiology·G E BisgardG S Mitchell
Dec 9, 2003·Journal of Applied Physiology·Ying-Jie Peng, Nanduri R Prabhakar
Jul 20, 2004·Journal of Applied Physiology·Ying-Jie PengNanduri R Prabhakar
Aug 21, 2004·The Journal of Physiology·Sergio ReyRodrigo Iturriaga
Dec 14, 2004·Journal of Applied Physiology·Insook KimJohn L Carroll
Apr 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Javier VilladiegoJuan J Toledo-Aral
Sep 3, 2005·Progress in Biophysics and Molecular Biology·S LahiriN R Prabhakar
Aug 5, 2006·The Journal of Physiology·Ying-Jie PengNanduri R Prabhakar

❮ Previous
Next ❯

Citations

Jun 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ying-Jie PengNanduri R Prabhakar
Jan 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jayasri NanduriNanduri R Prabhakar
Jul 29, 2010·American Journal of Physiology. Cell Physiology·Dangjai SouvannakittiNanduri R Prabhakar
Jun 17, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian J Koos
Dec 26, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anita PawarNanduri R Prabhakar
Jun 23, 2012·Journal of Applied Physiology·Nanduri R PrabhakarYing-Jie Peng
Sep 16, 2009·Neonatology·Justin A SteggerdaChristopher G Wilson
Oct 12, 2011·Neonatology·Richard J MartinPrabha Kc
Mar 17, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mary R Lovett-BarrGordon S Mitchell
Mar 6, 2013·The Journal of Physiology·Nanduri R Prabhakar
Apr 20, 2013·Respiratory Physiology & Neurobiology·E V FergusonR J A Wilson
Jul 31, 2012·Respiratory Physiology & Neurobiology·Peter M MacFarlaneRichard J Martin
Aug 21, 2012·Respiratory Physiology & Neurobiology·Estelle B GaudaRaul Chavez-Valdez
Aug 1, 2012·Respiratory Physiology & Neurobiology·Jayasri Nanduri, Nanduri R Prabhakar
Jun 12, 2012·Respiratory Physiology & Neurobiology·Margaret T T Wong-RileyXiu-ping Gao
May 26, 2011·Respiratory Physiology & Neurobiology·Cécile A JulienAida Bairam
May 31, 2011·Respiratory Physiology & Neurobiology·Nanduri R Prabhakar
Jan 18, 2011·Respiratory Physiology & Neurobiology·Jeffrey C RoeserRyan W Bavis
Feb 5, 2011·Respiratory Physiology & Neurobiology·Jason H Mateika, Kulraj S Sandhu
Sep 2, 2010·Respiratory Physiology & Neurobiology·Nanduri R PrabhakarJayasri Nanduri
Aug 5, 2009·Respiratory Physiology & Neurobiology·Stéphane VinitGordon S Mitchell
May 26, 2009·Respiratory Physiology & Neurobiology·David F DonnellyJohn L Carroll
Dec 17, 2008·Pediatric Pulmonology·Steve AbmanUNKNOWN NHLBI working group report
Jan 12, 2016·The Journal of Physiology·M QuinteroT Agapito
Nov 26, 2015·Clinics in Perinatology·Richard J MartinMichele C Walsh
Nov 20, 2015·Journal of Perinatology : Official Journal of the California Perinatal Association·J M Di FioreP MacFarlane
Jul 22, 2015·Experimental Physiology·Raphael R PerimBenedito H Machado
Jul 28, 2013·Respiratory Physiology & Neurobiology·Melissa L BatesMarlowe W Eldridge
Jun 28, 2011·Respiratory Physiology & Neurobiology·Jun CaiDavid Gozal
Jun 19, 2013·Respiratory Physiology & Neurobiology·Jan-Marino RamirezNanduri R Prabhakar
Jul 7, 2011·Respiratory Physiology & Neurobiology·Lucas M DonovanKingman P Strohl
Jun 2, 2016·Experimental Neurology·Ryan W Bavis, Peter M MacFarlane
Jun 1, 2016·Experimental Neurology·William H BarnettYaroslav I Molkov
Mar 25, 2016·Archives of Disease in Childhood. Fetal and Neonatal Edition·Sarah U Morton, Vincent C Smith
Mar 1, 2005·Respiratory Physiology & Neurobiology·Keisho KatayamaMiharu Miyamura
Nov 13, 2007·Journal of Science and Medicine in Sport·Martin Burtscher
Jul 31, 2016·Experimental Physiology·Nanduri R Prabhakar
Nov 20, 2016·The Journal of Physiology·Luana Tenorio-LopesRichard Kinkead
Jul 21, 2017·Journal of Neurophysiology·Casey O DiekmanChristopher G Wilson
Jun 14, 2018·Physiology·Bruce G LindseyKendall F Morris

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.