Comparative analysis of neuropeptide cleavage sites in human, mouse, rat, and cattle.

Mammalian Genome : Official Journal of the International Mammalian Genome Society
Allison N TeggeSandra L Rodriguez-Zas

Abstract

Neuropeptides are an important class of signaling molecules that result from complex and variable posttranslational processing of precursor proteins and thus are difficult to identify based solely on genomic information. Bioinformatics prediction of precursor cleavage sites can support effective biochemical characterization of neuropeptides. Neuropeptide cleavage models were developed using comprehensive human, mouse, rat, and cattle precursor data sets and used to compare predicted neuropeptide processing across these species. Logistic regression and artificial neural network models were used to predict cleavages based on amino acid and physiochemical properties of amino acids at precursor sequence locations proximal to cleavage. Correct cleavage classification rates across species and models ranged from 85% to 100%, suggesting that amino acid and amino acid properties have major impact on the probability of cleavage and that these factors have comparable effects in human, mouse, rat, and cattle. The variable accuracy of each species-specific model to predict cleavage sites indicated that there are species- and precursor-specific processing patterns. Prediction of mouse cleavages using rat models was highly accurate, yet the r...Continue Reading

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Citations

Dec 22, 2012·Journal of Proteome Research·Ji Eun LeeJonathan V Sweedler
Nov 17, 2012·BMC Genomics·Kenneth I PorterSandra L Rodriguez-Zas
Mar 21, 2009·Cellular and Molecular Life Sciences : CMLS·Mohamed Rholam, Christine Fahy
Oct 4, 2016·Database : the Journal of Biological Databases and Curation·Nadav BrandesMichal Linial
Apr 20, 2010·ACS Chemical Neuroscience·Larry J MilletMartha U Gillette
Apr 19, 2018·Journal of the American Society for Mass Spectrometry·Vivian HookOliver Fiehn
Oct 23, 2012·Journal of Proteome Research·Malik N AkhtarSandra L Rodriguez-Zas
Sep 25, 2021·Mass Spectrometry Reviews·Ashley PhetsanthadLingjun Li

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