Comparative analysis of plant immune receptor architectures uncovers host proteins likely targeted by pathogens.

BMC Biology
Panagiotis F SarrisKsenia V Krasileva

Abstract

Plants deploy immune receptors to detect pathogen-derived molecules and initiate defense responses. Intracellular plant immune receptors called nucleotide-binding leucine-rich repeat (NLR) proteins contain a central nucleotide-binding (NB) domain followed by a series of leucine-rich repeats (LRRs), and are key initiators of plant defense responses. However, recent studies demonstrated that NLRs with non-canonical domain architectures play an important role in plant immunity. These composite immune receptors are thought to arise from fusions between NLRs and additional domains that serve as "baits" for the pathogen-derived effector proteins, thus enabling pathogen recognition. Several names have been proposed to describe these proteins, including "integrated decoys" and "integrated sensors". We adopt and argue for "integrated domains" or NLR-IDs, which describes the product of the fusion without assigning a universal mode of action. We have scanned available plant genome sequences for the full spectrum of NLR-IDs to evaluate the diversity of integrations of potential sensor/decoy domains across flowering plants, including 19 crop species. We manually curated wheat and brassicas and experimentally validated a subset of NLR-IDs in...Continue Reading

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Methods Mentioned

BETA
RNA-seq
two-hybrid

Software Mentioned

FigTree
BIONJ
bioscripts
HMMER2
MEGA5
PhyloT
WebLogo
Integrated Genomics Viewer ( IGV ) tool
TOPHAT
hmmalign

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