PMID: 6165837May 1, 1981Paper

Comparative analysis of RNA genomes of mouse hepatitis viruses

Journal of Virology
M M Lai, S A Stohlman

Abstract

The RNA genomes of various murine hepatitis virus (MHV) strains were studied by T1-oligonucleotide fingerprinting analysis with regard to their structure and sequence relationship. It was found that the MHV particles contained only positive-stranded 60S RNA which had a "cap" structure at its 5' end. No negative-stranded RNA was found. It was also shown that most of the MHV strains had diverged quite extensively in their genetic sequences. However, MHV-3, a hepatotropic strain, and A59, a nonpathogenic strain, were found to have very similar oligonucleotide fingerprinting patterns. Yet, each of them contained two to four specific oligonucleotides. The MHV-3-specific oligonucleotides were conserved in almost all of the hepatotropic MHV strains studied. In contrast, two of the A59-specific oligonucleotides were absent from the genomes of all hepatotropic strains. These findings suggest that these unique oligonucleotides might be localized at the genetic region(s) associated with viral pathogenicity or other biological properties of the virus. Comparison of viral structural proteins also suggests that MHV-3 and A59 are more closely related than other MHV strains. The significance of these findings is discussed.

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Citations

Apr 28, 2010·PLoS Pathogens·Mickaël BouvetEtienne Decroly
Feb 6, 2016·Virologica Sinica·Yu Chen, Deyin Guo
Jan 1, 1983·Archives of Virology·M M LaiK Fujiwara
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Jan 1, 1988·Archives of Virology·S Dea, P Tijssen
Feb 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yu ChenDeyin Guo
Jul 31, 2014·The Journal of Biological Chemistry·Mickaël BouvetXavier Morelli
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Feb 4, 2014·The Journal of General Virology·Hongping DongPei-Yong Shi
Jan 23, 2021·Journal of Biomolecular Structure & Dynamics·Nilson Nicolau JuniorDiego Pandeló José
Aug 28, 2020·Molecular Cell·Fran RobsonWai-Lung Ng
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Apr 25, 2020·Cell·Dongwan KimHyeshik Chang

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