Comparative Analysis of Secretome of Human Umbilical Cord- and Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells

Bulletin of Experimental Biology and Medicine
Yu A RomanovG T Sukhikh

Abstract

Production of cytokines and growth factors by cultured human umbilical cord tissue- and bone marrow-derived multipotent mesenchymal stromal cells was measured by multiplex analysis. In most cases, the concentrations of bioactive factors in the culture medium conditioned by umbilical cord-derived cells was ten- to hundred-times higher than in the medium conditioned by bone marrow-derived cells. These results suggest that both multipotent mesenchymal stromal cells from the umbilical cord and cell-free products can have more pronounced therapeutic effect in comparison with mesenchymal stromal cells obtained from "adult" sources.

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Nov 26, 2015·Bulletin of Experimental Biology and Medicine·Yu A RomanovG T Sukhikh
Feb 24, 2016·Bulletin of Experimental Biology and Medicine·Yu A RomanovG T Sukhikh
Feb 28, 2017·Bulletin of Experimental Biology and Medicine·Yu A RomanovG T Sukhikh
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Mar 11, 2018·Stem Cell Research & Therapy·Somayeh KeshtkarMohammad Hossein Ghahremani

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Citations

May 19, 2019·International Journal of Molecular Sciences·Dariusz BoruczkowskiIzabela Zdolińska-Malinowska
Jun 12, 2019·Bulletin of Experimental Biology and Medicine·Yu A RomanovG T Sukhikh
Jan 29, 2021·World Journal of Stem Cells·Alberto González-GonzálezFlor M Pérez-Campo
Mar 17, 2021·Bulletin of Experimental Biology and Medicine·M I EzdakovaE R Andreeva
Dec 24, 2021·Advanced Biology·Sirine Yassine, Nada Alaaeddine

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