Comparative Analysis of Serum Proangiogenic Biomarkers between those with and without Diabetic Retinopathy

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
Tayyaba Gul MalikEiman Ayesha

Abstract

To compare the serum proangiogenic biomarkers in diabetic patients suffering from with and without diabetic retinopathy (DR). An observational study. Arif Memorial Teaching Hospital, Lahore, Pakistan and Institute of Molecular Biology and Biotechnology/Centre for Research in Molecular Medicine, The University of Lahore, Lahore, Pakistan, from March to December 2017. Forty patients with DR were included in group A and 15 patients without retinopathy (controls) were included in group B. Twelve serum pro-angiogenic biomarkers [Angiopoietin 2, Human Growth Factor (HGF), Epidermal Growth Factor (EGF), Fibroblast Growth Factor (FGF), Placental Growth Factor (PLGF), Vascular Endothelial Growth Factor-A and C (VEGF-A and VEGF-C), Bone Morphogenetic Protein 9 (BMP9), Follistatin, Leptin, Interleukin-8 (IL8), Endothelin (ET)] were analysed by xMAP flow cytometry technique, results were compared between the two groups and statistical analysis was done using Mann-Whitney U test. Serum ET, Follistatin and EGF were significantly raised in group A as compared to group B having p-values of 0.001, <0.001, and 0.033, respectively. Serum BMP9, Leptin, HGF, FGF and VEGF-C had p <0.001, 0.023, 0.020, and 0.009, respectively and were higher in group...Continue Reading

Citations

Jan 16, 2020·Journal of Clinical Medicine·Bogusz FalkowskiDorota Zozulinska-Ziolkiewicz
Feb 13, 2020·Journal of Immunoassay & Immunochemistry·Anas Ahmad, Haseeb Ahsan

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