Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats.

Frontiers in Endocrinology
Yildiz KelahmetogluJorge L Ruas

Abstract

Increasing exercise capacity promotes healthy aging and is strongly associated with lower mortality rates. In this study, we analyzed skeletal muscle transcriptomics coupled to exercise performance in humans and rats to dissect the inherent and response components of aerobic exercise capacity. Using rat models selected for intrinsic and acquired aerobic capacity, we determined that the high aerobic capacity muscle transcriptome is associated with pathways for tissue oxygenation and vascularization. Conversely, the low capacity muscle transcriptome indicated immune response and metabolic dysfunction. Low response to training was associated with an inflammatory signature and revealed a potential link to circadian rhythm. Next, we applied bioinformatics tools to predict potential secreted factors (myokines). The predicted secretome profile for exercise capacity highlighted circulatory factors involved in lipid metabolism and the exercise response secretome was associated with extracellular matrix remodelling. Lastly, we utilized human muscle mitochondrial respiration and transcriptomics data to explore molecular mediators of exercise capacity and response across species. Human transcriptome comparison highlighted epigenetic mechan...Continue Reading

References

Mar 21, 1998·Medicine and Science in Sports and Exercise·C BouchardJ H Wilmore
Sep 16, 1998·Lancet·G ErikssenJ Erikssen
Feb 13, 2001·Physiological Genomics·L G Koch, S L Britton
Jun 28, 2001·Medicine and Science in Sports and Exercise·C Bouchard, T Rankinen
Mar 15, 2002·The New England Journal of Medicine·Jonathan MyersJ Edwin Atwood
Sep 18, 2002·Journal of Applied Physiology·Kyle K HendersonNorberto C Gonzalez
Dec 14, 2005·Respiratory Physiology & Neurobiology·Norberto C GonzalezPeter D Wagner
Apr 28, 2006·Journal of Anatomy·Michael KjaerHenning Langberg
Jun 8, 2006·Annual Review of Biochemistry·Rhonda Bassel-Duby, Eric N Olson
Apr 21, 2007·Nature Protocols·Olof EmanuelssonHenrik Nielsen
Apr 2, 2008·Molecular and Cellular Biology·Mi-Sung KimEric N Olson
May 20, 2008·Nucleic Acids Research·Valer Gotea, Ivan Ovcharenko
Jan 6, 2009·Medicine and Science in Sports and Exercise·Molly S BrayClaude Bouchard
Feb 11, 2009·Medicine and Science in Sports and Exercise·Susan B SissonTimothy S Church
Mar 4, 2010·Molecular Endocrinology·Scott M EbertChristopher M Adams
Jul 21, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Riikka KiveläHeikki Kainulainen
Sep 17, 2011·Circulation Research·Lauren Gerard KochUlrik Wisløff
Aug 8, 2012·Trends in Cardiovascular Medicine·Lauren Gerard KochUlrik Wisløff
May 30, 2013·Physiological Genomics·Lauren Gerard KochSteven L Britton
Aug 24, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·David D McManusJane E Freedman
Jun 26, 2014·American Journal of Physiology. Endocrinology and Metabolism·E Matthew MorrisJohn P Thyfault
Nov 25, 2014·Cell·John A HawleyJuleen R Zierath
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders
Nov 12, 2015·Frontiers in Physiology·Tim SnijdersGianni Parise
May 29, 2016·The Journal of Physiology·Mark A SarzynskiClaude Bouchard
Sep 13, 2016·Nature Reviews. Drug Discovery·Martin Whitham, Mark A Febbraio
Apr 9, 2017·Cold Spring Harbor Perspectives in Medicine·Lauren Gerard Koch, Steven L Britton
May 4, 2017·American Journal of Physiology. Endocrinology and Metabolism·Samuel K PintoDonny M Camera
May 12, 2017·Cold Spring Harbor Perspectives in Medicine·David C HughesKeith Baar
May 13, 2017·Science·Peter J ThulEmma Lundberg
Jul 1, 2017·Journal of Lipid Research·Michael S KuefnerEdwards A Park
Aug 10, 2018·Experimental Dermatology·In Wook KimDong-Seok Kim

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Datasets Mentioned

BETA
GSE155230
GSE97084

Methods Mentioned

BETA
biopsies
RNA-seq
sequence-based prediction

Clinical Trials Mentioned

NCT01477164
NCT01738568

Software Mentioned

FastQC
IPA
Ingenuity
Ingenuity Pathway Analysis
DIRE
Ingenuity Pathway Analysis ( IPA )
WolfPsort
Cufflinks
DESeq2
SignalP

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