Comparative Analysis of the Effects of Olive Oil Hydroxytyrosol and Its 5-S -Lipoyl Conjugate in Protecting Human Erythrocytes from Mercury Toxicity

Oxidative Medicine and Cellular Longevity
Arbace OfficiosoCaterina Manna

Abstract

Oxidative stress is one of the underlying mechanisms of the toxic effects exerted by mercury (Hg) on human health. Several antioxidant compounds, including the olive oil phenol hydroxytyrosol (HT), were investigated for their protective action. Recently, we have reported that 5-S-lipoylhydroxytyrosol (Lipo-HT) has shown increased antioxidant activities compared to HT and exerted potent protective effects against reactive oxygen species (ROS) generation and oxidative damage in human hepatocellular carcinoma HepG2 cell lines. In this study, the effects of Lipo-HT and HT on oxidative alterations of human erythrocytes induced by exposure to 40 μM HgCl2 were comparatively evaluated. When administered to the cells, Lipo-HT (5-20 μM) proved nontoxic and it decreased the Hg-induced generation of ROS, the hemolysis, and the depletion of intracellular GSH levels. At all tested concentrations, Lipo-HT exhibited higher ability to counteract Hg-induced cytotoxicity compared to HT. Model studies indicated the formation of a mercury complex at the SH group of Lipo-HT followed by a redox reaction that would spare intracellular GSH. Thus, the enhanced erythrocyte protective action of Lipo-HT from Hg-induced damage with respect to HT is likely d...Continue Reading

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Citations

Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marina PiscopoCaterina Manna
Aug 24, 2019·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Cuneyt CaglayanMuhammet Bahaeddin Dortbudak
Jul 3, 2021·International Journal of Molecular Sciences·Rosaria NotarialeCaterina Manna
Oct 27, 2020··Istiqomah RahmawatiRizki Fitria Darmayanti

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Methods Mentioned

BETA
scanning electron microscopy

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