Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements.

Genes & Development
S M HanlyW C Greene

Abstract

The Rex proteins of types I and II human T-cell leukemia viruses (HTLV-I, HTLV-II) are required for expression of the viral structural gene products, gag and env and, thus, are essential for the replication of these pathogenic retroviruses. The action of Rex is sequence specific, requiring the presence of a cis-acting Rex response element located in the 3' long terminal repeat. This element corresponds to a predicted RNA secondary structure and functions in an orientation-dependent but position-independent manner. Rex acts through this response element to stimulate the nuclear export of the unspliced or singly spliced viral mRNA species encoding the virion structural proteins that are normally excluded from the cytoplasm. Although the Rex proteins of HTLV-I and HTLV-II can also function via the related Rev response element present in the env gene of the type I human immunodeficiency virus (HIV-1), the analogous HIV-1 Rev protein is unable to act on the HTLV-I Rex response element. This nonreciprocal pattern of genetic complementation by Rex and Rev suggests that these viral trans-regulators may interact directly with their RNA response elements.

References

Sep 16, 1976·Nature·N J Proudfoot, G G Brownlee
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S MatsushitaS Broder
May 1, 1989·Journal of Virology·M L HammarskjöldD Rekosh
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B K FelberG N Pavlakis
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C A RosenW A Haseltine
Dec 1, 1988·Journal of Virology·J HauberB R Cullen
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N SagataY Ikawa
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J InoueM Seiki
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y WanoW C Greene
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M SeikiM Yoshida
Feb 1, 1988·Journal of Virology·E TerwilligerC Rosen
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J HauberB R Cullen
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J SodroskiW A Haseltine
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·N SagataY Ikawa
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K ShimotohnoI S Chen
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M SeikiM Yoshida
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T R CechP S Perlman

❮ Previous
Next ❯

Citations

Jan 1, 1990·Molecular Biology Reports·I W Mattaj
May 24, 1995·Molecular and Cellular Biochemistry·R A FinchP K Chan
Jan 1, 1995·Journal of Biomedical Science·A.A. Franklin, J.K. Nyborg
Dec 23, 2003·International Journal of Hematology·Genoveffa FranchiniJake R Fullen
Dec 18, 2008·Apoptosis : an International Journal on Programmed Cell Death·Nicola VajenteDaniela Saggioro
Dec 1, 2011·Apoptosis : an International Journal on Programmed Cell Death·Giovanna StoppaDaniela Saggioro
Jun 1, 1997·Blood Reviews·O C FerreiraJ D Rosenblatt
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·H P BogerdW C Greene
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T UngeG N Pavlakis
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L J Zhao, C Z Giam
Jul 28, 2009·The Journal of Biological Chemistry·Jennifer A MertzJaquelin P Dudley
Oct 9, 1999·AIDS Research and Human Retroviruses·D M D'AgostinoL Chieco-Bianchi
Oct 7, 2008·Nucleic Acids Research·Matthias MüllnerStanislav Indik
Aug 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J H KimR R Redfield
Feb 3, 1999·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·G C NewboundM D Lairmore
Dec 17, 2010·Journal of Virology·Jochen BodemAxel Rethwilm
Nov 12, 2005·Journal of Virology·Jennifer A MertzJaquelin P Dudley
Jan 19, 1999·Annual Review of Microbiology·V W Pollard, M H Malim
Mar 1, 1991·The Journal of Clinical Investigation·M R Smith, W C Greene
Jun 14, 2005·Retrovirology·Clemens FurnesAnne Marie Szilvay
Oct 14, 2011·Viruses·Ilaria CavallariVincenzo Ciminale
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·C CaronP Jalinot
Aug 8, 2001·International Journal of Experimental Pathology·J M JohnsonG Franchini
Sep 26, 2001·Experimental Cell Research·D SaggioroL Chieco-Bianchi
Jul 30, 2014·Frontiers in Microbiology·Hyewon ByunJaquelin P Dudley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.