PMID: 7546250Apr 1, 1995Paper

Comparative analysis of the immunophenotypes of decidual and peripheral blood large granular lymphocytes and T cells during early human pregnancy

American Journal of Reproductive Immunology : AJRI
A GeiselhartR Handgretinger

Abstract

The functional role of the leukocytes in the decidual is not clear. They may regulate the maternal immune response to the fetal allograft. However, the factors controlling maternal and fetal communication have not yet been identified. A comparative analysis of the phenotypes of decidual and peripheral blood large granular lymphocytes (LGLs) and T lymphocytes in early human pregnancy was performed on decidual tissue and blood samples obtained from ten patients at therapeutic abortion. Whereas most of the decidual LGLs were found to have a CD56bright++ phenotype, most of the peripheral blood NK cells (90%) showed the classical CD56dim+ phenotype, and only a small proportion were CD56bright+ cells. Another striking difference was found in the expression of very late antigen 1 (VLA-1, CD49a): Almost all the decidual CD56bright++ LGLs, but virtually none of the peripheral blood CD56+ NK cells expressed this antigen. Further differences were found in the expression of CD16, CD44, CD45RA, CD54, and CD57. There were also differences in phenotype between T cells derived from decidual tissue and those derived from peripheral blood. Approximately 31% of the CD3+ decidual T cells expressed VLA-1, but this antigen was virtually absent on pe...Continue Reading

References

Nov 1, 1978·The Journal of Pathology·C J Jones, H Fox
Jan 1, 1992·Gynecologic and Obstetric Investigation·J DietlD Kabelitz
Dec 1, 1991·Immunology Today·A King, Y W Loke
Oct 1, 1991·American Journal of Obstetrics and Gynecology·L J DungyS Khan
Jun 1, 1989·The Journal of Experimental Medicine·L L LanierJ H Phillips
May 1, 1985·European Journal of Immunology·M E HemlerJ L Strominger
Jan 1, 1987·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·S RandallH Fox
Sep 1, 1983·American Journal of Reproductive Immunology : AJRI·C B CoulamC G Fathman
Aug 5, 1982·The New England Journal of Medicine·V SridamaL J DeGroot
Apr 1, 1958·Obstetrics and Gynecology·H HAMPERL, G HELLWEG

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Citations

Feb 1, 1996·American Journal of Reproductive Immunology : AJRI·L MatthiesenL Håkansson
Jun 22, 1999·American Journal of Reproductive Immunology : AJRI·I BedenickiS E Christmas
May 18, 1999·American Journal of Reproductive Immunology : AJRI·L MatthiesenL Håkansson
Jun 17, 2009·American Journal of Reproductive Immunology : AJRI·Rafael Gustavo VargasMaria da Graça Bicalho
Sep 29, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Shomron Ben-Horin, Ilan Bank
Mar 1, 1996·Current Biology : CB·M DiehlH G Rammensee
Apr 29, 2016·Nature Reviews. Immunology·Niklas K BjörkströmJakob Michaëlsson
Sep 3, 2014·Journal of the National Cancer Institute·Antonino BrunoDouglas M Noonan
Oct 1, 1996·Immunology and Cell Biology·H S Warren
Sep 5, 2002·Nature Reviews. Immunology·Ashley Moffett-King
May 20, 2020·The Journal of Obstetrics and Gynaecology Research·Jorge Valencia-OrtegaJosé G Cruz-Durán
May 31, 2018·The Cochrane Database of Systematic Reviews·Roger E Thomas, Diane L Lorenzetti
Jul 8, 2014·The Cochrane Database of Systematic Reviews·Roger E Thomas, Diane L Lorenzetti
Mar 15, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana Sofia CerdeiraHernan D Kopcow
Aug 30, 2018·Frontiers in Immunology·Paola VaccaLorenzo Moretta
Jul 12, 2003·American Journal of Reproductive Immunology : AJRI·A Sindram-TrujilloF Claas
Jan 1, 2015·Frontiers in Immunology·Elisa MontaldoMaria Cristina Mingari
Oct 6, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L D FrenkelF Sabahi
Jun 19, 2002·American Journal of Reproductive Immunology : AJRI·Olga NagaevaLucia Mincheva-Nilsson
May 30, 2021·American Journal of Reproductive Immunology : AJRI·Xueling ZhangYong Zeng

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