Comparative analysis of the uterine and mammary gland effects of drospirenone and medroxyprogesterone acetate.

Endocrinology
Christiane OttoKarl-Heinrich Fritzemeier

Abstract

The role of progestins in combined hormone therapy is the inhibition of uterine epithelial cell proliferation. The Women's Health Initiative study provided evidence for an increased risk of breast cancer in women treated with conjugated equine estrogens plus the synthetic progestin medroxyprogesterone acetate (MPA), compared with conjugated equine estrogens-only treatment. These findings continue to be discussed, and it remains to be clarified whether the results obtained for MPA in the Women's Health Initiative study are directly applicable to other progestins used in hormone therapy. In this study we compared in a mouse model the effects of the synthetic progestins, MPA, and drospirenone in two major target organs: the uterus and mammary gland. As quantitative measures of progestin activity, we analyzed maintenance of pregnancy, ductal side branching in the mammary gland, and proliferation of mammary and uterine epithelial cells as well as target gene induction in both organs. The outcome of this study is that not all synthetic progestins exhibit the same effects. MPA demonstrated uterine activity and mitogenic activity in the mammary gland at the same doses. In contrast, drospirenone behaved similarly to the natural hormone,...Continue Reading

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Citations

Apr 24, 2009·Molecular and Cellular Biochemistry·Jean-Claude MarshallPatricia S Steeg
Apr 14, 2010·Menopause : the Journal of the North American Menopause Society·Mads NielsenClaus Christiansen
Aug 5, 2009·Chemical & Pharmaceutical Bulletin·Jianjun ChenWei Li
Apr 24, 2009·Climacteric : the Journal of the International Menopause Society·C PanoulisG Creatsas
Nov 5, 2014·Climacteric : the Journal of the International Menopause Society·M LiX Li
Nov 27, 2009·Climacteric : the Journal of the International Menopause Society·T Simoncini, A R Genazzani
Oct 8, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Hakan KiranHasan Cetin Ekerbicer
May 20, 2020·Scientific Reports·Andréia Latanza Gomes MathezMagnus Régios Dias-da-Silva
Feb 16, 2012·Endocrinology·Christiane OttoReinhold G Erben
Aug 30, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jiang-Wei ZhangLing Yang
Nov 29, 2017·Statistics in Medicine·Frank BretzMatthias Trampisch
Mar 20, 2021·Biostatistics·Kathrin MöllenhoffFrank Bretz

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