Comparative analysis of transforming growth factor-beta isoforms 1-3 in human and rabbit dentine matrices

Archives of Oral Biology
N CassidyA J Smith

Abstract

Previous studies have implicated transforming growth factor-beta (s)(TGF-beta) in both development. Here TGF-beta isoforms in dentine extracellular matrix were analysed because these molecules may participate in dental issue repair. EDTA-soluble and collagenase-released fractions were isolated from human crown and root and rabbit incisor dentine samples and analysed for TGF-beta isoforms. TGF-beta(1) was the major isoform detected in all samples and the only isoform detected in human dentine samples. TGF-beta(2) was detected only in the collagenase-released fraction of rabbit incisor dentine and was present at low levels. TGF-beta(3) was detected in both EDTA-soluble and collagenase-released fractions of rabbit dentine. Greater levels of the TGF-beta(1) isoform were detected in the rabbit than human dentine samples and some differences in distribution amongst the two tissue fractions were observed between these species. The presence of these isoforms of TGF-beta in dentine may provide a reservoir of growth factor in the matrix that could participate in processes leading to tissue repair after injury.

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Citations

Feb 14, 2008·Clinical Oral Investigations·A J SmithP R Cooper
Sep 23, 2000·Archives of Oral Biology·D J Roberts-Clark, A J Smith
Mar 29, 2003·Archives of Oral Biology·Julia L McLachlanPaul R Cooper
Mar 15, 2000·Archives of Oral Biology·A J SloanA J Smith
Dec 14, 2001·Journal of Dentistry·Peter E MurrayAnthony J Smith
Mar 5, 2003·Journal of Dentistry·P E MurrayA J Smith
Feb 10, 2000·Journal of Dentistry·D TziafasH Lesot
Mar 21, 2000·Journal of Dentistry·P E MurrayA J Smith
Apr 21, 2005·Development, Growth & Differentiation·Muhetaer HuojiaMasamichi Ohishi
Mar 25, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Kotaro SaitoHayato Ohshima
Apr 5, 2014·Journal of Endodontics·Anibal R DiogenesKenneth M Hargreaves
Jul 28, 2012·Dental Clinics of North America·Sahng G KimJeremy J Mao
Dec 15, 2010·Journal of Endodontics·Rong ZhangAnthony J Smith
May 12, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Na Ryoung KimHyeong-Cheol Yang
Dec 25, 2015·Journal of Endodontics·Anthony J SmithPaul R Cooper
Jun 15, 2007·Journal of Dentistry·Phillip L TomsonPaul R Cooper
Feb 27, 2008·International Endodontic Journal·P E MurrayP J Lumley
Sep 17, 2010·Cell Biology International·Mei-Ying ShaoTao Hu
Dec 6, 2012·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·Neeraj Malhotra, Kundabala Mala
Dec 20, 2002·Connective Tissue Research·K DobieA J Smith
Dec 20, 2002·Connective Tissue Research·Marion LucchiniJean-Christophe Farges
Sep 21, 2011·Archives of Oral Biology·Wenjian Zhang, Jun Ju
Jul 27, 2000·Experimental Cell Research·I AboutT A Mitsiadis
Mar 15, 2000·The Journal of the American Dental Association·P E MurrayA J Smith
Aug 23, 2011·Archives of Oral Biology·A J SmithP R Cooper
Jan 18, 2015·Journal of Endodontics·Kerstin M GallerGottfried Schmalz
Dec 25, 2013·Odontology·Wannakorn SriarjHitoyata Shimokawa
Jun 4, 2016·Journal of Biomedical Materials Research. Part a·Fahimeh Sadat TabatabaeiKeyvan Moharamzadeh
Apr 5, 2014·Journal of Endodontics·Paul R CooperAnthony J Smith

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