Comparative analysis of viral infection outcomes in human seminal fluid from prior viral epidemics and Sars-CoV-2 may offer trends for viral sexual transmissibility and long-term reproductive health implications.

Reproductive Health
James Frederick W PikeRenee J Chosed

Abstract

Viral detection in seminal fluid indicates their potential for both sexual transmission and impairment of reproductive health. Review of the mechanistic entry, sexual transmission and viral impacts for patients during major recent viral outbreaks of Zika virus (ZIKV), Ebola virus (EBOV), severe acute respiratory syndrome (SARS)-coronavirus (CoV), and SARS-coronavirus 2 (CoV-2) (the virus which causes COVID-19) provides a framework to discuss this potential. Comparative analysis of prior viral presence on seminal fluid against current (preliminary) findings for SARS-CoV-2 to predict biological implications of the novel coronavirus upon current sexual transmissibility, viral presence, and reproductive health. Literature review was conducted using PubMed and Google Scholar databases. ZIKV and EBOV were found to be present in semen and to be sexually transmitted, leading the World Health Organization (WHO) to update their guidelines on prevention of the two viruses to include refraining from sexual contact. There are conflicting studies regarding the presence of SARS-CoV in male reproductive tissue, but it has been linked to testicular atrophy and orchitis. To date, two studies have detected SARS-CoV-2 RNA in semen, while seven stu...Continue Reading

References

Jun 24, 2005·The New England Journal of Medicine·Yoshihiro Kawaoka
Jul 27, 2005·The Journal of Experimental Medicine·Jiang GuAnthony S-Y Leong
May 3, 2011·Emerging Infectious Diseases·Brian D FoyRobert B Tesh
Oct 16, 2015·The New England Journal of Medicine·Suzanne E MateGustavo Palacios
Oct 16, 2015·The New England Journal of Medicine·Gibrilla F DeenFoday Sahr
Feb 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Audrey Stéphanie RichardHyeryun Choe
Oct 14, 2017·The Journal of Infectious Diseases·Markus H KainulainenChristina F Spiropoulou
Oct 20, 2017·Emerging Infectious Diseases·Alex P Salam, Peter W Horby
Feb 13, 2018·The American Journal of Pathology·Donna L PerryReed F Johnson
Apr 12, 2018·The New England Journal of Medicine·Paul S MeadAlison F Hinckley
Apr 12, 2018·The New England Journal of Medicine·Heinz Feldmann
Mar 19, 2019·Emerging Infectious Diseases·Jean-Michel MansuyNabila Jabrane-Ferrat
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Mar 23, 2020·The Lancet Infectious Diseases·Yang LiuWei Zhang
Apr 12, 2020·Cancer Discovery·Konrad H StopsackPhilip W Kantoff
Apr 17, 2020·Biology of Reproduction·Ci SongYun Liu
Jun 9, 2020·BioRxiv : the Preprint Server for Biology·Hanbing SongFranklin W Huang
Jul 1, 2020·Andrology·Liqiang GuoMingzhen Yuan
Jul 12, 2020·Fertility and Sterility·Nora HoltmannAlexandra Petra Bielfeld
Aug 12, 2020·Urologia Internationalis·Bircan KayaaslanRahmet Guner
Sep 3, 2020·Open Forum Infectious Diseases·Stephen A RawlingsAntoine Chaillon
Jan 28, 2021·Cell·Xiu NieTiannan Guo
Feb 10, 2021·Infectious Disease Reports·Bruno MachadoRodney Davis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica
Héctor Rodriguez BustosCamilo Arriaza Onel
Middle East Fertility Society Journal
Indu SharmaSubhas Chandra Saha
Journal of the Chinese Medical Association : JCMA
Hsin-Hui HuangCheng-Chang Chang
© 2021 Meta ULC. All rights reserved