Comparative Analysis of Zebrafish and Planarian Model Systems for Developmental Neurotoxicity Screens Using an 87-Compound Library

Toxicological Sciences : an Official Journal of the Society of Toxicology
Danielle HagstromEva-Maria S Collins

Abstract

There is a clear need to establish and validate new methodologies to more quickly and efficiently screen chemicals for potential toxic effects, particularly on development. The emergence of alternative animal systems for rapid toxicology screens presents valuable opportunities to evaluate how systems complement each other. In this article, we compare a chemical library of 87-compounds in 2 such systems, developing zebrafish and freshwater planarians, by screening for developmental neurotoxic effects. We show that the systems' toxicological profiles are complementary to each other, with zebrafish yielding more detailed morphological endpoints and planarians more behavioral endpoints. Overall, zebrafish was more sensitive to this chemical library, yielding 86/87 hits, compared with 50/87 hits in planarians. The difference in sensitivity could not be attributed to molecular weight, log Kow, or the bioconcentration factor. Of the 87 chemicals, 28 had previously been evaluated in mammalian developmental neuro- (DNT), neuro-, or developmental toxicity studies. Of the 28, 20 were hits in the planarian, and 27 were hits in zebrafish. Eighteen of the 28 had previously been identified as DNT hits in mammals and were highly associated wit...Continue Reading

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Aug 9, 2016·Regeneration·Danielle HagstromEva-Maria S Collins
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Citations

Oct 27, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Katharina DachPamela J Lein
Jul 6, 2019·Médecine sciences : M/S·Laetitia PoirierÉric Chabrière
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Subham DasguptaRobyn L Tanguay
Nov 19, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Johnathan MorrisMary M Staehle

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