Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: molecular and evolutionary perspectives

Cellular and Molecular Life Sciences : CMLS
Cátia L MarquesVincent Laizé

Abstract

BMP2, BMP4 and BMP16 form a subfamily of bone morphogenetic proteins acting as pleiotropic growth factors during development and as bone inducers during osteogenesis. BMP16 is the most recent member of this subfamily and basic data regarding protein structure and function, and spatio-temporal gene expression is still scarce. In this work, insights on BMP16 were provided through the comparative analysis of structural and functional data for zebrafish BMP2a, BMP2b, BMP4 and BMP16 genes and proteins, determined from three-dimensional models, patterns of gene expression during development and in adult tissues, regulation by retinoic acid and capacity to activate BMP-signaling pathway. Structures of Bmp2a, Bmp2b, Bmp4 and Bmp16 were found to be remarkably similar; with residues involved in receptor binding being highly conserved. All proteins could activate the BMP-signaling pathway, suggesting that they share a common function. On the contrary, stage- and tissue-specific expression of bmp2, bmp4 and bmp16 suggested the genes might be differentially regulated (e.g. different transcription factors, enhancers and/or regulatory modules) but also that they are involved in distinct physiological processes, although with the same function...Continue Reading

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Citations

Jan 26, 2018·BMC Evolutionary Biology·Ajay Ramakrishnan VaradarajanPatrick T McGrath
Apr 23, 2019·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Masatoshi MatsunamiToshinori Hayashi
Mar 7, 2021·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Chun-Hong NieZe-Xia Gao
Mar 18, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Martin R SilicGuangJun Zhang

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