PMID: 2510238Jan 1, 1989Paper

Comparative and combined effects of transforming growth factors alpha and beta, interleukin-1 and interferon-gamma on rheumatoid synovial cell proliferation, glycolysis and prostaglandin E production

Rheumatology International
D J TaylorD E Woolley

Abstract

Enhanced cell proliferation, glycolysis and prostaglandin E production are all characteristic features of rheumatoid synovial tissue. The interrelationships of these three cellular parameters have been examined using rheumatoid synovial fibroblasts and their responses to specific cytokines in vitro. Transforming growth factor alpha (TGF alpha) caused a more than threefold increase in synovial cell proliferation whilst transforming growth factor beta (TGF beta), interleukin-1 alpha (IL-1 alpha) and interferon-gamma (IFN-gamma) produced only marginal changes. The combined addition of IL-1 alpha with TGF beta resulted in an enhanced proliferative response comparable with that produced by TGF alpha. Glycolysis, estimated by glucose utilisation and measurements of the glycolytic regulatory metabolite fructose 2,6-bisphosphate was significantly stimulated by TGF beta, IL-1 alpha and IFN-gamma, but less so by TGF alpha. Prostaglandin E production was significantly increased by IL-1 alpha to an extent much greater than that produced by TGF alpha or TGF beta, although the combined addition of IL-1 alpha with either TGF alpha or beta resulted in a synergistic increase in PGE production, a response partly diminished by the addition of IFN...Continue Reading

References

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Jan 1, 1988·Scandinavian Journal of Rheumatology. Supplement·H G Fassbender, S Gay
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Citations

Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J A HamiltonA K Royston
Apr 1, 1994·Annals of the Rheumatic Diseases·D L MatteyP T Dawes
Jan 5, 2012·Internal Medicine·Antonietta RizzoRossella Paolillo
Mar 7, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina D SwansonWilliam H Robinson

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