PMID: 7541618Mar 1, 1995Paper

Comparative anti-HIV evaluation of diverse HIV-1-specific reverse transcriptase inhibitor-resistant virus isolates demonstrates the existence of distinct phenotypic subgroups

Antiviral Research
R W BuckheitM R Boyd

Abstract

We have biologically and biochemically evaluated a structurally diverse group of HIV-1-specific reverse transcriptase (RT) inhibitors and determined that the members of this class share many common properties. These include reproducible and selective antiviral activity against a panel of biologically distinct laboratory and clinical strains of HIV-1, activity against HIV-1 in a wide variety of cultured and fresh human cells, and potent inhibition of HIV-1 RT when evaluated using a heteropolymeric ribosomal RNA template assay. Each of the HIV-1-specific compounds was capable of inhibiting HIV replication when challenged at high m.o.i., further distinguishing them from the nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). When tested in combination with AZT, each of the HIV-1-specific compounds synergistically inhibited the replication of HIV-1. HIV-1 isolates resistant to different HIV-1-specific inhibitors exhibited heterogeneous patterns of cross-resistance to other members of this pharmacologic class. Four distinct phenotypic classes have been defined through the use of drug-resistant virus isolates which derive from distinct mutations in the RT. These results indicate that the various subgr...Continue Reading

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Citations

Feb 18, 1999·Bioorganic & Medicinal Chemistry Letters·Z Q XuM T Flavin
Mar 23, 2005·Virology·András HorváthJanos Aradi
Oct 23, 2014·The Journal of Antimicrobial Chemotherapy·Alessandro Cozzi-LepriUNKNOWN CHAIN Minority HIV-1 Variants Working Group
Jun 3, 2016·Chemistry : a European Journal·Ying ChengCarsten Bolm
Jun 12, 2002·Bioorganic & Medicinal Chemistry·Guozhang XuMark Cushman
Oct 10, 2014·International Journal of Toxicology·Lillian C BeckerF Alan Andersen
Mar 11, 2018·Biochemistry. Biokhimii︠a︡·V T Valuev-Elliston, S N Kochetkov
Dec 29, 2020·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Wenting ZhengQingle Zeng
Aug 1, 1996·Journal of Natural Products·T C McKeeM R Boyd
Jul 2, 2021·Advances in Virology·Maria S Serna-ArbeláezWildeman Zapata

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