PMID: 2502799Jan 1, 1989Paper

Comparative anxiogenic, neuroendocrine, and other physiologic effects of m-chlorophenylpiperazine given intravenously or orally to healthy volunteers

Psychopharmacology
D L MurphyF M Jacobsen

Abstract

The serotonin agonist m-chlorophenylpiperazine (m-CPP) had greater anxiogenic and other mood and cognitive effects when administered intravenously (0.1 mg/kg) rather than orally (0.5 mg/kg) to healthy subjects. Nonetheless, similar elevations in peak plasma cortisol and prolactin concentrations were obtained with the two dosage regimens, and temperature elevations were greater after oral m-CPP. Plateau phase plasma concentrations of m-CPP at the times of the maximum neuroendocrine responses to intravenous and oral m-CPP were similar. Since all rodent and nonhuman primate studies have used parenterally administered m-CPP, and previous clinical investigations using intravenous rather than oral m-CPP have yielded somewhat discrepant results, our normative data should be useful for comparing results across different human studies and across species.

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Citations

Jan 1, 1992·Journal of Neural Transmission. General Section·E Chojnacka-Wójcik, A Kłodzińska
Jan 1, 1991·Journal of Neural Transmission. General Section·H S Lee, H Y Meltzer
Feb 1, 1994·Psychopharmacology·R S KahnL Siever
Jan 1, 1992·Psychopharmacology·K P LeschH M Schulte
Dec 1, 1991·Biological Psychiatry·R S Kahn, S Wetzler
Mar 1, 1992·Biological Psychiatry·H S LeeH Y Meltzer
Apr 1, 1995·Biological Psychiatry·U HalbreichK Wang
Jan 1, 1993·Life Sciences·L N Yatham, M Steiner
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·L D SanfordG L Mann
Jan 1, 1992·Molecular Aspects of Medicine·A C Power, P J Cowen
Jun 1, 1991·Psychiatry Research·S WetzlerH M van Praag
Dec 9, 2003·European Journal of Pharmacology·Hemmie H G Berendsen, Helenius J Kloosterboer
Sep 1, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nic J A van der WeeHerman G M Westenberg
Dec 4, 1998·Biological Psychiatry·S RotzingerG B Baker
Nov 10, 1998·Biological Psychiatry·D R RubinowC A Roca
Mar 4, 1998·Journal of Psychosomatic Research·M BourinJ Bradwejn

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