Comparative aspects of congener specific PCB metabolism

European Journal of Drug Metabolism and Pharmacokinetics
J T Borlakoglu, C H Walker

Abstract

Despite the large number of PCB congeners identified (in some environmental samples more than 70 isomers and congeners) only some 12 of them account for 80% of the total PCB adipose tissue burden. These compounds are a selective group of PCBs which are highly chlorinated or alternatively lack meta-para-vicinal protons. Comparison of the persistent and non-persistent PCB congeners between human adipose tissue, human breast milk and fish-eating sea birds revealed similarities in the bioaccumulation pattern. These findings suggest a certain inability of cytochrome P-450 mono-oxygenases to metabolise a specific group of PCBs.

References

Jun 1, 1973·Bulletin of Environmental Contamination and Toxicology·Y A GreichusR J Emerick
Dec 1, 1974·Bulletin of Environmental Contamination and Toxicology·V ZitkoP M Choi
Jan 1, 1972·Residue Reviews·D B Peakall
Apr 1, 1972·Environmental Health Perspectives·O HutzingerV Zitko
Apr 1, 1972·Environmental Health Perspectives·I C Nisbet, A F Sarofim
Sep 14, 1973·Science·H S Bennett, P W Albro
May 1, 1969·Bulletin of Environmental Contamination and Toxicology·L M Reynolds

❮ Previous
Next ❯

Citations

Dec 1, 1993·Zeitschrift Für Lebensmittel-Untersuchung Und -Forschung·J HajslovaV Raverdino
Dec 1, 1990·Bulletin of Environmental Contamination and Toxicology·J T BorlakogluR R Dils
Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J T Borlakoglu, P John
Jul 14, 1998·Chemosphere·J SheR D Stephens
May 5, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D L ArnoldS Malcolm
Nov 9, 2004·Environmental Health Perspectives·Mike HowsamUNKNOWN Bellvitge Colorectal Cancer Group
Jan 1, 1995·Critical Reviews in Toxicology·R D Kimbrough
Oct 18, 2014·Environmental Toxicology and Chemistry·Agnès FournierCatherine Jondreville
Jun 8, 2011·Journal of Environmental and Public Health·George W YuCharles Mylander
Sep 4, 2015·The Science of the Total Environment·Manuel E Ortiz-SantaliestraRafael Mateo
Mar 5, 2016·Reviews on Environmental Health·Zafar AminovDavid O Carpenter
Apr 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J T BorlakogluR R Dils
Oct 6, 1997·Journal of Toxicology and Environmental Health·B L FinleyD J Paustenbach
Oct 1, 1989·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C H Walker, M J Ronis
Mar 20, 1992·Journal of Chromatography·V Lang
Dec 1, 1996·Chemical Research in Toxicology·E K WehlerB O Lund

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.