Comparative aspects of the care of familial hypercholesterolemia in the "Ten Countries Study"

Journal of Clinical Lipidology
Jing PangGerald F Watts

Abstract

There is a lack of information on the health care of familial hypercholesterolemia (FH). The objective of this study was to compare the health care of FH in countries of the Asia-Pacific region and Southern Hemisphere. A series of questionnaires were completed by key opinion leaders from selected specialist centers in 12 countries concerning aspects of the care of FH, including screening, diagnosis, risk assessment, treatment, teaching/training, and research; the United Kingdom (UK) was used as the international benchmark. The estimated percentage of patients diagnosed with the condition was low (overall <3%) in all countries, compared with ∼15% in the UK. Underdetection of FH was associated with government expenditure on health care (ϰ = 0.667, P < .05). Opportunistic and systematic screening methods, and the Dutch Lipid Clinic Network criteria were most commonly used to detect FH; genetic testing was infrequently used. Noninvasive imaging of coronary calcium and/or carotid plaques was underutilized in risk assessment. Patients with FH were generally not adequately treated, with <30% of patients achieving guideline recommended low-density lipoprotein cholesterol targets on conventional therapies. Treatment gaps included subopt...Continue Reading

Citations

Jan 3, 2020·JAMA Cardiology·UNKNOWN Representatives of the Global Familial Hypercholesterolemia CommunitySamuel S Gidding
Aug 15, 2020·Frontiers in Genetics·Chin-Chou Huang, Min-Ji Charng
Sep 19, 2020·Current Atherosclerosis Reports·Sergei N PokrovskyMarat V Ezhov
Aug 9, 2019·Current Opinion in Cardiology·Raul D Santos
Jan 25, 2020·Nature Reviews. Cardiology·Gerald F WattsKausik K Ray
Feb 26, 2020·Current Opinion in Cardiology·Hapizah Md NawawiGerald F Watts
Jan 5, 2021·Expert Opinion on Drug Delivery·Mduduzi N SitholeMinja Gerber
Jan 19, 2021·Journal of Atherosclerosis and Thrombosis·Yung-An ChuaHapizah Nawawi
Mar 23, 2021·Journal of Atherosclerosis and Thrombosis·Sanjay KalraHung-I Yeh
Jul 31, 2021·American Journal of Preventive Cardiology·Jian-Jun LiStephen J Nicholls
Nov 2, 2019·Progress in Cardiovascular Diseases·Marcio H Miname, Raul D Santos
Dec 7, 2021·The Journal of Clinical Endocrinology and Metabolism·Wael E EidCarl Miller

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