Comparative aspects of the strength of pulmonary capillaries in rabbit, dog, and horse

Respiration Physiology
E K BirksJ B West

Abstract

In previous studies of rabbit and dog lung, we demonstrated stress failure of pulmonary capillaries at high transmural pressures (Ptm). The Ptm necessary to elicit stress failure was 40 cmH2O higher in dog than rabbit, and the total blood-gas barrier (BGB) thickness was greater in dog than rabbit. This suggests that stress failure may be related to BGB thickness, and is consistent with the Laplace relationship which states that wall stress is proportional to capillary radius but inversely proportional to wall thickness. In the present studies, we compared BGB thickness and an index of capillary radius in lungs from 3 rabbits, 3 dogs, and 2 horses perfusion fixed at a Ptm of approximately 30 cmH2O. Thicknesses of the BGB were measured at right angles to the barrier at random points on the capillary wall determined by test line intersections. Capillary radius was determined from the mean of major and minor axes measured on electron micrographs. Capillary pressure for failure in the horse was taken to be the mean of pulmonary arterial and left atrial pressures observed in galloping thoroughbreds known to develop exercise-induced pulmonary hemorrhage, although the actual pressure required for failure may be less than this. Average ...Continue Reading

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Citations

Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·J B West, O Mathieu-Costello
Feb 27, 2007·European Journal of Applied Physiology·John R Fitz-Clarke
Sep 1, 1996·Respiration Physiology·I AyappaS J Lai-Fook
Jun 10, 2000·Journal of Veterinary Pharmacology and Therapeutics·J H MagidS Ghantous
Aug 15, 1998·Equine Veterinary Journal·T S MeyerH H Erickson
Oct 31, 2002·Equine Veterinary Journal. Supplement·E K BirksC E Uboh
Apr 1, 1999·Annual Review of Physiology·J B West, O Mathieu-Costello
Apr 18, 2009·Journal of Applied Physiology·Andrew T LoveringMarlowe W Eldridge
Mar 14, 2013·BioMed Research International·Andrew MakanyaValentin Djonov
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·D Dreyfuss, G Saumon
Jul 29, 2004·American Journal of Respiratory and Critical Care Medicine·UNKNOWN ad hoc Statement Committee, American Thoracic Society
Oct 27, 2007·American Journal of Respiratory Cell and Molecular Biology·Ming-Yuan JianMary I Townsley
Jul 17, 2001·American Journal of Veterinary Research·W W MuirJ Gadawski
Feb 19, 2016·Parasites & Vectors·R Alan WilsonWilliam Castro-Borges
Jan 25, 2006·Respiratory Physiology & Neurobiology·John B WestZhenxing Fu
May 31, 2012·TheScientificWorldJournal·Manuel García-DelgadoEnrique Fernández-Mondéjar
Apr 11, 2015·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·John N Maina
Sep 3, 2004·Critical Care Medicine·Alain F BroccardMarie-Denise Schaller
Aug 1, 1995·Circulation·J B West, O Mathieu-Costello
Nov 23, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rebecca R WatsonJohn B West
Apr 5, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Zhenxing FuJohn B West
Oct 3, 2006·Current Opinion in Anaesthesiology·T Hachenberg, R Rettig
May 4, 2013·Journal of Applied Physiology·John B West
Aug 7, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·John B West
Oct 19, 2000·Equine Veterinary Journal·P FunkquistS G Persson
Oct 1, 2003·Equine Veterinary Journal·C A KindigH H Erickson
Dec 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Andrew T LoveringMarlowe W Eldridge
Mar 18, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Zhenxing FuJohn B West
Oct 19, 2000·Equine Veterinary Journal·I LangsetmoH H Erickson
Jun 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·Emily E FriedrichAsrar B Malik

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