Comparative assessment of best conventional with best theta burst repetitive transcranial magnetic stimulation protocols on human motor cortex excitability

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
N ZafarMartin Sommer

Abstract

Comparative assessment of best conventional with best theta burst repetitive transcranial magnetic stimulation (rTMS) protocols on human motor cortex excitability. Stimulation of dominant hand abductor digiti minimi muscle representation of motor cortex in nine healthy right-handed subjects utilising two different MagPro stimulators to generate TMS pulses of distinct monophasic, half sine and biphasic shape with anteriorly or posteriorly directed current flow, measuring resting and active motor threshold and motor-evoked potential (MEP) amplitude. Comparison of two different conventional rTMSs and eight different theta burst stimulation (TBS) protocols. Continuous TBS (cTBS) yielded an inhibition, and intermittent TBS (iTBS) a facilitation of MEP amplitudes. These effects were not significantly influenced by waveform or current orientation. Compared to conventional rTMS paradigms, neither cTBS nor iTBS showed significantly stronger effects. In addition and confirming earlier findings, the asymmetric monophasic pulse and a posteriorly directed current flow yielded a higher threshold than all other TMS types. The less asymmetric half-sine pulse had a lower threshold for postero-anterior current than in the opposite direction. The...Continue Reading

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Mar 17, 2009·Brain Topography·Lizbeth Cárdenas-MoralesCarlos Schönfeldt-Lecuona
Jun 5, 2012·Cerebral Cortex·Masashi HamadaJohn C Rothwell
Jan 12, 2011·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Lindsay ObermanAlvaro Pascual-Leone
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