PMID: 6104792Apr 1, 1980Paper

Comparative assessment of beta-adrenoceptor blocking agents as simple competitive antagonists in isolated heart muscle: similarity of inotropic and chronotropic blocking potencies against isoproterenol

Naunyn-Schmiedeberg's Archives of Pharmacology
A J KaumannJ R Blinks

Abstract

The pattern of antagonism between isoproterenol and various beta-adrenoceptor blocking agents was explored in spontaneously beating right atria and in driven left atrial strips from kittens and guinea pigs. The onset of beta-adrenoceptor blockade is usually very slow in such preparations; incubation periods of up to an hour may be required for equilibrium conditions. The speed of onset of the blocking action is directly related to the concentration of the antagonist, and therefore, for a given degree of blockade, inversely related to its potency. beta-Adrenoceptor blocking agents were found to interact with isoproterenol in a manner consistent with a simple competitive antagonism provided that (1) the antagonist had little intrinsic stimulant action on the preparation under study, (2) the concentrations of antagonist used had no direct depressant action on the preparation, (3) precautions were taken to assure that the pattern of antagonism was not distorted by loss of agonist into tissue sinks, and (4) dose-response curves were normalized for changes in the baseline frequency or force in successive curves. Corrections for desensitization were necessary only in inotropic dose-response curves. Estimates of the equilibrium dissoci...Continue Reading

References

Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·B B WolfeP B Molinoff
May 1, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·A J Kaumann, L Birnbaumer
Dec 17, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·W KrawietzC Konrad
May 1, 1978·British Journal of Pharmacology·P Chenieux-GuicheneyH Schmitt
Nov 1, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·A J Kaumann
Jul 1, 1978·British Journal of Pharmacology·E J CornishR C Miller
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·A J Kaumann
Jul 3, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·H BönischU Trendelenburg
Jun 12, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·H Bönisch, U Trendelenburg
Feb 10, 1967·Annals of the New York Academy of Sciences·J R Blinks
Sep 1, 1970·European Journal of Pharmacology·M Bristow, R D Green
Nov 1, 1970·British Journal of Pharmacology·A M Barrett, J Carter
Sep 1, 1973·European Journal of Pharmacology·W Wöppel, U Trendelenburg
Feb 10, 1967·Annals of the New York Academy of Sciences·R F Furchgott
Jul 1, 1965·Journal of Applied Physiology·J R Blinks
Apr 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·A J Kaumann, J R Blinks
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Apr 21, 1964·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·J R BLINKS

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Citations

Aug 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·T H MorrisA J Kaumann
Apr 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·A J Kaumann, J R Blinks
Jul 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·E Skoubo-Kristensen, J Fryklund
Apr 25, 1989·European Journal of Pharmacology·P Y MarieR J Royer
Oct 22, 1984·Life Sciences·C ChassaingP Duchêne-Marullaz
Nov 1, 1993·British Journal of Pharmacology·A D Medhurst, A J Kaumann
Dec 1, 1992·International Journal of Cardiology·S H HohnloserH Just
Jan 22, 1985·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E F ShibataG H Pollack
Mar 23, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D W Hilgemann, D Noble
Nov 1, 1993·Medicinal Research Reviews·J R Arch, A J Kaumann
Sep 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·T H Morris, A J Kaumann
Jan 1, 1986·International Journal of Immunopharmacology·L Sterin-BordaS Passeron

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