Comparative assessment of distribution of blackcurrant anthocyanins in rabbit and rat ocular tissues

Experimental Eye Research
Hitoshi MatsumotoHiroshi Ohguro

Abstract

Anthocyanins (ACs) are phenolic compounds that are distributed widely in fruits and vegetables. Although consumption of these compounds has been shown to improve visual function, the distribution of ACs in ocular tissue has not been examined in detail. The aim of this study was therefore to evaluate the ocular distribution of blackcurrant anthocyanins (BCAs) in rats and rabbits after oral, intravenous (i.v.) and intraperitoneal (i.p.) administration. Identification and quantification of ACs were carried out using high-performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-ESI-MS) and high-performance liquid chromatography (HPLC) with UV-visible detection, respectively. BCAs were identified in the plasma and whole eye after oral and i.p. administration in rats. No other peaks were detected in either plasma or ocular tissues after administration when the absorbance of the eluate was monitored at 520 nm. This finding indicates that intact forms of ACs were present in rats after administration of BCA. In rats given i.p. administration, the concentration of total ACs in the whole eye and some ocular tissues was higher than that measured in plasma. These results suggested that ACs detected in the ocular tis...Continue Reading

References

Apr 21, 2001·Journal of Agricultural and Food Chemistry·H MatsumotoM Hirayama
Apr 27, 2001·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·C BeauregardG C Chiou
Oct 31, 2002·Journal of Biochemical and Biophysical Methods·Ursula MüllederWerner Pfannhauser
May 6, 2003·The Journal of Nutrition·Catherine FelginesChristian Rémésy
May 29, 2003·Journal of Agricultural and Food Chemistry·Hitoshi MatsumotoMasao Hirayama
Mar 17, 2004·Free Radical Biology & Medicine·Takashi IchiyanagiTetsuya Konishi
Sep 29, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Annalucia SerafinoEnrico Garaci
Jan 6, 2005·Journal of Agricultural and Food Chemistry·Takashi IchiyanagiTetsuya Konishi

❮ Previous
Next ❯

Citations

Mar 2, 2010·The British Journal of Nutrition·Catherine FelginesOdile Texier
Oct 20, 2010·The British Journal of Nutrition·Daniele Del RioAlan Crozier
Apr 23, 2011·Journal of Natural Products·Andreja VanzoSabina Passamonti
Aug 15, 2012·Journal of Nutrition in Gerontology and Geriatrics·Paul E Milbury
Oct 11, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hiroshi OhguroSaeko Yagi
Dec 25, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kaori YoshidaHiroshi Ohguro
Feb 5, 2009·Photochemistry and Photobiology·Naveena YanamalaJudith Klein-Seetharaman
Oct 23, 2014·Journal of Agricultural and Food Chemistry·Wilhelmina KaltFrancois Tremblay
Aug 1, 2008·Nutrition Reviews·Michael Rhone, Arpita Basu
Sep 26, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Claudia Di GiacomoFabio Galvano
Oct 12, 2014·Experimental Eye Research·Rania S SulaimanTimothy W Corson
Jul 27, 2012·The Journal of Nutritional Biochemistry·François TremblayWilhelmina Kalt
Jan 17, 2016·Annual Review of Food Science and Technology·Mary Ann LilaWilhelmina Kalt
Feb 24, 2007·Journal of Pharmaceutical and Biomedical Analysis·Jie XingHongxiang Lou
Aug 5, 2009·Molecular Nutrition & Food Research·Catherine FelginesAugustin Scalbert
Jun 3, 2011·Phytotherapy Research : PTR·Junji TanakaHideaki Hara
Jul 29, 2010·The Journal of Pharmacy and Pharmacology·Soumyajit Majumdar, Ramesh Srirangam
Nov 22, 2011·Molecular Nutrition & Food Research·Takanori Tsuda
Mar 24, 2016·Critical Reviews in Food Science and Nutrition·Giovana Bonat CelliMarianne Su-Ling Brooks
Feb 15, 2014·BioMed Research International·Dorota Bonarska-KujawaHalina Kleszczyńska
Sep 22, 2010·Molecular Aspects of Medicine·Alan CrozierMichael N Clifford
Apr 10, 2012·Biochemical Pharmacology·Claudio BucoloSalvatore Salomone
Dec 10, 2016·Photochemistry and Photobiology·Sally M Yacout, Elizabeth R Gaillard
Apr 1, 2017·Journal of Agricultural and Food Chemistry·Yixiang LiuBaoping Ji
Mar 2, 2012·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Hiroshi OhguroSachie Tanaka
Sep 7, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Seiji MiyakeYoko Ozawa
Jun 8, 2012·Food & Function·Ashwin GopalanAnupam Bishayee
Jul 3, 2019·Nutrients·Bogdan Nicolae ManolescuIleana C Farcasanu
Jul 23, 2019·Advances in Nutrition·Wilhelmina KaltRaul Zamora-Ros
Sep 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuri NomiHitoshi Matsumoto
May 26, 2016·Phytotherapy Research : PTR·Antonella SmeriglioDomenico Trombetta
Mar 17, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hong-Wei DengJing Meng
May 11, 2018·Cutaneous and Ocular Toxicology·Lan-Hsin ChuangChi-Chun Lai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.