Comparative assessment of five serum antimüllerian hormone assays for the diagnosis of polycystic ovary syndrome

Fertility and Sterility
P PignyD Dewailly

Abstract

To determine whether the different antimüllerian hormone (AMH) immunoassays on the market offer the same performance for the diagnosis of polycystic ovary syndrome (PCOS). A total of 95 serum AMH samples were retrospectively evaluated for a period of 3 months in the same laboratory. Academic center laboratory. Forty-eight control women with regular menses and no hyperandrogenism and 47 patients with classic PCOS (i.e., hyperandrogenism plus oligoanovulation) attending our department for infertility. None. AMH measurement using five commercial assays. Method comparison and evaluation of the diagnostic performance by receiver operating characteristic analysis. Values obtained with Gen II and AL-105i ELISAs were similar to those provided by EAI AMH/MIS, whereas automatic assays generated lower values. A significant mean difference was observed between Access Dxi (1.35 ng/mL) or Cobas (1.73 ng/mL) and EIA AMH/MIS ELISA. By ROC analysis each assay displayed similar efficiency for PCOS diagnosis. Sensitivities varied from 49% to 74% when setting the specificity at 92%. Cluster analysis run in the control group identified a subgroup of asymptomatic women with polycystic ovary morphology (PCOM). After exclusion of PCOM, the 95th percen...Continue Reading

References

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Citations

May 7, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Didier Dewailly
Nov 3, 2016·Clinical Endocrinology·S L JacobJ H Barth
Jun 10, 2017·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Rachel A BradburyHoward C Smith
Jul 7, 2017·Clinical Endocrinology·Molly M QuinnUNKNOWN NIH/NICHD Reproductive Medicine Network
Oct 10, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Agathe DumontDidier Dewailly
Aug 29, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Antonio La MarcaMartina Capuzzo
Jul 16, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Seyedeh Atiye Shahrokhi, Amirmansour Alavi Naeini
Oct 31, 2019·Case Reports in Endocrinology·Aurore CatteauDamien Masson
Jul 14, 2020·Therapeutic Advances in Reproductive Health·Preetham Rao, Priya Bhide
Dec 5, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Vivek KakkadTejas Gundewar
Feb 2, 2021·Endocrinology and Metabolism Clinics of North America·John S Rushing, Nanette Santoro
Feb 27, 2021·Frontiers in Endocrinology·Martina Capuzzo, Antonio La Marca
Feb 27, 2021·Reproductive Biomedicine Online·Geoffroy RobinDidier Dewailly
Nov 11, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sarah DesongnisSophie Catteau-Jonard
Oct 24, 2018·Journal of Gynecology Obstetrics and Human Reproduction·Mathilde VictoriaMichaël Grynberg
May 29, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Mikaël AgopiantzGuillaume Gauchotte
Mar 28, 2021·The Journal of Clinical Endocrinology and Metabolism·Benjamin S HarrisAnne Marie Jukic
May 17, 2017·Gynécologie, Obstétrique, Fertilité & Sénologie·Y DadounC Decanter
Oct 2, 2017·Gynécologie, Obstétrique, Fertilité & Sénologie·M PeignéP Pigny

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