Comparative assessment of mouse models for experimental orthodontic tooth movement.

Scientific Reports
Christian KirschneckAgnes Schröder

Abstract

Animal experiments are essential for the elucidation of biological-cellular mechanisms in the context of orthodontic tooth movement (OTM). So far, however, no studies comparatively assess available mouse models regarding their suitability. OTM of first upper molars was induced in C57BL/6 mice either via an elastic band or a NiTi coil spring for three, seven or 12 days. We assessed appliance survival rate, OTM and periodontal bone loss (µCT), root resorptions, osteoclastogenesis (TRAP+ area) and local expression of OTM-related genes (RT-qPCR). Seven days after the elastic bands were inserted, 87% were still in situ, but only 27% after 12 days. Survival rate for the NiTi coil springs was 100% throughout, but 8.9% of the animals did not survive. Both methods induced significant OTM, which was highest after 12 (NiTi spring) and 7 days (band), with a corresponding increase in local gene expression of OTM-related genes and osteoclastogenesis. Periodontal bone loss and root resorptions were not induced at a relevant extent by neither of the two procedures within the experimental periods. To induce reliable OTM in mice beyond 7 days, a NiTi coil spring is the method of choice. The elastic band method is recommended only for short-term ...Continue Reading

References

Apr 1, 1994·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·W G GrieveL M DuBois
Mar 1, 1993·The Journal of Bone and Joint Surgery. British Volume·K S LeungK M Lee
Apr 29, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R A DoddsM Gowen
Jul 23, 1998·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·L Bondemark
Mar 30, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R A DoddsM Gowen
Dec 20, 2005·Gene·Janet RubinChristopher Rae Jacobs
Apr 22, 2006·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Vinod Krishnan, Ze'ev Davidovitch
Aug 29, 2006·The American Journal of Pathology·Toshihisa KawaiMartin A Taubman
Aug 19, 2007·European Journal of Orthodontics·Sabrina Carvalho GomesRui Vicente Oppermann
Apr 4, 2008·The Journal of the American Dental Association·Anne-Marie BollenPhilippe P Hujoel
May 8, 2009·Orthodontics & Craniofacial Research·M Yamaguchi
Oct 21, 2009·European Journal of Orthodontics·Yuji FujimuraNoriaki Yoshida
Apr 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Emanuela Ricciotti, Garret A FitzGerald
Aug 4, 2011·European Journal of Orthodontics·Masahide MotokawaKazuo Tanne
Aug 9, 2011·Archives of Oral Biology·Masako YoshimatsuNoriaki Yoshida
Sep 19, 2012·European Journal of Orthodontics·Melissa GrantIain Chapple
Oct 6, 2012·Journal of Biomechanics·Silvana Rodrigues de Albuquerque TaddeiTarcília Aparecida da Silva
Sep 3, 2013·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Takahiro YabumotoShigemi Goto
Nov 5, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Christian KirschneckPiero Roemer
Jul 6, 2014·Journal of Orthodontic Science·Nazeer Ahmed Meeran
Jul 31, 2014·European Journal of Orthodontics·Zaki HakamiTeruko Takano-Yamamoto
Oct 15, 2014·European Journal of Orthodontics·Vasiliki KoretsiPiero Römer
Mar 22, 2015·Journal of Dental Research·H KanzakiY Nakamura
Dec 18, 2015·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Alja PlutMartina Drevenšek
Dec 23, 2015·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Christian KirschneckPiero Römer
Jan 11, 2017·Innate Immunity·Michael WolfAndreas Jäger
Apr 16, 2018·The Kaohsiung Journal of Medical Sciences·Yina LiChing-Chang Ko
Dec 1, 2016·Turkish Journal of Orthodontics·Furkan Dindaroğlu, Servet Doğan
Jun 13, 2019·Nature Reviews. Immunology·Masayuki Tsukasaki, Hiroshi Takayanagi
May 20, 2020·Scientific Reports·Yehuda KleinStella Chaushu

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Citations

Jun 10, 2021·Journal of Dental Research·S ChaushuO Fleissig
Aug 7, 2021·Biomedicines·Christian KirschneckAgnes Schröder
Aug 9, 2021·Archives of Oral Biology·Andressa V B NogueiraJoni A Cirelli

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