Comparative assessment of rest and post-stress left ventricular volumes and left ventricular ejection fraction on gated myocardial perfusion imaging (MPI) and echocardiography in patients with transient ischaemic dilation on adenosine MPI: myocardial stunning or subendocardial hypoperfusion?

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Louise EmmettLeonard Kritharides

Abstract

Transient ischaemic dilation (TID) on myocardial perfusion imaging (MPI) is an important finding, conveying a high risk of subsequent cardiac events. However, the mechanism leading to TID on MPI is not well elucidated. This study aimed to determine if TID is due to true LV cavity dilation and ventricular stunning, or is due to relative subendocardial hypoperfusion. 31 patients undergoing single-day Tc-99m adenosine sestamibi MPI were recruited. All had routine ECG-gated single-day rest-stress adenosine MPI, with transthoracic echocardiograms (echo) acquired concurrently at rest, and both immediately, and 2 hours, post-stress. Echocardiography was performed using a Vivid-7 (GE). LV volumes and LVEF were quantified blinded to MPI results, using biplane Simpson method on echo, and quantitatively (including TID) with QGS(®), on MPI. Patients were divided into quartiles for TID, with the top quartile considered TID positive [TID+ 9/31 (TID ratio 1.3 ± 0.09)], and TID negative [TID- 22/31 (TID ratio 1.01 ± 0.04)]. There was good correlation between resting echo and MPI physical measurements (LVEDV r(2) = 0.79, LVESV r(2) = 0.9, and LVEF r(2) = 0.75). On MPI, a significant drop in LVEF was observed between rest and early stress in the...Continue Reading

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Citations

Oct 24, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mario PetrettaAlberto Cuocolo
Aug 10, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Rami DoukkyRussell F Kelly
Aug 26, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wael AlJaroudi
Apr 1, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Yasmeen GolzarRami Doukky
Jun 18, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Zenith A JameriaMyron C Gerson
Aug 31, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Eliana Reyes, Fadi G Hage
Jan 24, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Vita Tomas, Vita Nestor
Jul 11, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Eliana Reyes
Dec 6, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jorge CamillettiErick Alexanderson-Rosas

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