Comparative assessment of the anaesthetic and analgesic effects of intramuscular and epidural clonidine in humans

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
E SamsóM M Puig

Abstract

The aim of the study was to assess and compare in analogous controlled experimental conditions, the anaesthetic sparing and analgesic effects of the same dose of clonidine administered by the intramuscular (im) and epidural (ep) routes. We used a randomized, double blind and placebo controlled protocol. Sixty patients undergoing abdominal hysterectomy were distributed into three groups who, 30 min before surgical incision, received: 300 micrograms ep clonidine plus im saline; ep saline plus 300 micrograms im clonidine; or ep and im saline (ss). General anaesthesia was maintained with 60% N2O in O2, and isoflurane administered at concentrations to maintain mean arterial pressure (MAP) and heart rate (HR) within 20% of basal values. Isoflurane requirements (mass spectrometry), cardiovascular variables (MAP, HR), and plasma concentrations of glucose, cortisol and prolactin were evaluated at critical time points. In the recovery room (RR), sedation (Ramsay) and pain intensity (VAS) were estimated at the time of analgesia request (TAR). Intramuscular and ep clonidine decreased isoflurane requirements similarly by about 85% (P < 0.001). Patients in the ep group had lower MAP (P < 0.03) and HR (P < 0.001) than in the im group, but im ...Continue Reading

References

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Citations

Dec 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A N Sandler
Oct 14, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A H El SaiedJ M Ansermino
Apr 4, 1998·Journal of Clinical Anesthesia·J VallèsM M Puig
Jul 26, 2006·Anesthesia Progress·David L HallJohn D Walters
Apr 1, 1997·Expert Opinion on Investigational Drugs·J P Hieble, R R Ruffolo
Sep 15, 2004·Pain·Ahmet Dogrul, Tayfun I Uzbay
Mar 15, 2002·Anesthesiology Clinics of North America·Mark W Farrar, Jerrold Lerman
Aug 26, 2006·Journal of Dental Research·D L HallE Rezvan
Sep 4, 2015·The Cochrane Database of Systematic Reviews·Anna WrzosekJerzy Wordliczek
Jul 11, 2006·Current Opinion in Anaesthesiology·Arthur W Wallace
Apr 26, 2002·Anesthesia and Analgesia·Luis CasatiMargarita M Puig

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