PMID: 15248628Jul 14, 2004Paper

Comparative assessment of the effects of alfentanil, esmolol or clonidine when used as adjuvants during induction of general anaesthesia

European Journal of Anaesthesiology
S Fernandez-GalinskiM M Puig

Abstract

This randomized, double-blinded, prospective study compared the effects of clonidine, esmolol or alfentanil on the level of hypnosis and haemodynamic responses to intravenous induction of anaesthesia and endotracheal intubation. Forty-five patients scheduled for elective surgery were allotted to one of three groups. They were given either alfentanil 3 microg kg(-1) min(-1) (n = 15); esmolol 1 mg kg(-1) min(-1) (n = 16) or clonidine 3 microg kg(-1) (n = 14) as a 10 min infusion. The infusions of alfentanil and esmolol, but not of clonidine, were maintained during endotracheal intubation. Anaesthesia was induced with midazolam (2 mg) and thiopental as required to suppress the eyelash reflex. Atracurium (0.5 mg kg(-1)) was given to produce neuromuscular block. Mean arterial pressure, heart rate, and bispectral index were recorded on arrival (baseline), after study drug infusion, after injecting midazolam and thiopental, as well as after endotracheal intubation. ANOVA and chi2-test were used for analysis. Blood pressure, heart rate and the bispectral index were unaltered by the study drugs, but thiopental requirements were reduced by alfentanil and clonidine (P < 0.014). Mean arterial pressure values (mean +/- standard error of mea...Continue Reading

References

Feb 1, 1993·Anesthesia and Analgesia·I Kissin
Jun 1, 1997·Current Opinion in Pediatrics·B FivushS Furth
Dec 4, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y FujiiH Toyooka
Jan 13, 1999·European Journal of Anaesthesiology·A W WoodsJ A Davidson
Mar 1, 2000·Acta Anaesthesiologica Scandinavica·F MarinangeliG Varrassi
Sep 16, 2000·Intensive Care Medicine·S Murdoch, A Cohen
Sep 29, 2001·British Journal of Anaesthesia·J E HallT J Ebert

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Citations

Oct 6, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Giovanni LandoniAlberto Zangrillo
Jun 15, 2007·Journal of Intensive Care Medicine·Thomas C Mort
Aug 25, 2012·The Heart Surgery Forum·Nobuhisa ItoHiromitsu Teratani

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