Comparative assessment of transient exposure of paclitaxel or zotarolimus on in vitro vascular cell death, proliferation, migration, and proinflammatory biomarker expression

Journal of Cardiovascular Pharmacology
Donald S SteinfeldJulie T Tai

Abstract

Both paclitaxel and zotarolimus are currently employed in vascular interventional therapies, such as drug-eluting stents, and are under investigation for use in other novel drug-device combination products. Paclitaxel is a microtubule-stabilizing compound with potent antiproliferative properties and antimigration effects, whereas zotarolimus is a potent mammalian target of rapamycin inhibitor with antiproliferative and antiinflammatory properties. This study was intended to compare paclitaxel and zotarolimus for intravascular applications in which drug exposure time may be reduced, such as in drug-coated balloons. These applications are generally aimed at reducing neointimal hyperplasia by limiting smooth muscle cell (SMC) proliferation and inflammatory cell recruitment, while minimally interfering with vessel reendothelialization after balloon denudation. In the cellular models described in this study, transient exposure of zotarolimus resulted in the sustained inhibition of SMC proliferation and reduced endothelial cell (EC) proinflammatory cytokine expression, while not affecting EC migration and viability. Transient exposure of paclitaxel inhibited SMC proliferation, EC migration, and overall cell viability, with no effect ...Continue Reading

References

Apr 1, 1992·Journal of the American College of Cardiology·A M LincoffE J Topol
Mar 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·B L Coomber, A I Gotlieb
Jun 1, 1995·Molecular and Cellular Probes·E S MansfieldP Fortina
Oct 1, 1994·Journal of the American College of Cardiology·A N TenagliaJ E Tcheng
Feb 7, 1998·The Biochemical Journal·J R Wu-WongT J Opgenorth
Jun 7, 2000·Journal of the American College of Cardiology·C HerdegK R Karsch
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C SgadariB Ensoli
Sep 4, 2004·Coronary Artery Disease·Renu VirmaniFrank D Kolodgie
Aug 24, 2005·Antioxidants & Redox Signaling·Andreas Schober, Christian Weber
Feb 21, 2006·Journal of the American College of Cardiology·Rainer WesselyAdnan Kastrati
Mar 15, 2006·Cancer Chemotherapy and Pharmacology·Taisuke MoriHideo Honjo
Mar 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi FunayamaMasanobu Kawakami
Apr 4, 2006·Advanced Drug Delivery Reviews·Sandra E BurkeLewis B Schwartz
Nov 15, 2006·The New England Journal of Medicine·Bruno SchellerUlrich Speck
Feb 27, 2007·Vascular Health and Risk Management·Martin Schillinger, Erich Minar
Apr 17, 2007·European Heart Journal·Heleen M M van BeusekomWillem J van der Giessen
Sep 20, 2007·Expert Opinion on Drug Safety·Neena I MarupudiHenry Brem
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos
Aug 2, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Pål AukrustJan K Damås
May 2, 2009·Annals of Biomedical Engineering·Marie A PunchardValerie Barron
Jun 10, 2009·International Journal of Immunopathology and Pharmacology·J SzkodzinskiB Zubelewicz-Szkodzinska
Oct 6, 2009·The Journal of Veterinary Medical Science·Ben-Dong FuYukio Hara
Jul 28, 2010·Heart·Adrian P Banning, Chris C S Lim

❮ Previous
Next ❯

Citations

Aug 9, 2015·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Keiichiro MiuraYoshio Kobayashi
Jun 21, 2015·Vascular Pharmacology·Janine HussnerHenriette E Meyer Zu Schwabedissen
Apr 21, 2018·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Ting-Chao LinI-Ming Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.