Comparative behaviour of the components of the factor VIII complex in acute myocardial infarction

Thrombosis Research
M P CucuianuL Pechet

Abstract

The three components of the factor VIII complex: VIII coagulant (VIII:C), VIII related antigen (VIII R:Ag) and the VIII related von Willebrand factor (VIII R:WF) were studied in patients with acute myocardial infarction (AMI). Using a carefully standardized technique for the determination of VIII R:WF, a significantly higher R:WF level was found in 32 patients compared to 19 control subjects, confirming our previous results. However VIII R:AG was increased to an even greater extent, resulting in a VIII R:Ag/VIII R:WF ratio of 1.58 +/- 0.084 in patients, compared to 1.21 +/- 0.045 in controls. A similar increase of the VIII R:AG/VIII:C ratio was noted in the 13 patients in whom VIII:C was investigated. In 7 patients with severe AMI who could be investigated twice the plasma levels of both VIII R:Ag and VIII R:WF were found to be lower a week after the acute event than during the first 48 hours. However the VIII R:Ag/VIII R:WF ratio was not significantly reduced after 7 days. Acute phase reaction and endothelial injury resulting in release of multimers which are less polymerised are probably involved in the above changes.

References

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Citations

Oct 22, 2008·Blood·Anetta UndasKenneth G Mann
May 1, 1992·European Journal of Epidemiology·F R Rosendaal
Apr 13, 2006·European Journal of Haematology·Bea TanisFrits Rosendaal
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May 16, 2002·Experimental and Molecular Pathology·Annette M MüllerC James Kirkpatrick

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