Comparative bio-availability and activity of proprietary topical corticosteroid preparations: vasoconstrictor assays on thirty-one ointments

The British Journal of Dermatology
B W Barry, R Woodford

Abstract

Thirty-one proprietary corticosteroid ointments were evaluated for vasoconstriction using an occluded blanching test. The results were expressed as three parameters: (1) area under the blanching curve, (2) summed % total possible score, and (3) square root transformation of sum of scores divided by number of volunteers. Experiments were performed to (a) compare the bio-availability and activity of the ointments, (b) determine the effect of antimicrobial additivies, and (c) assess the retention of steroids in the skin. Scores for the additivie-containing and 'plain' preparations were within 90% except for Locorten-Vioform/Locorten (58%). A steroid reservoir in the skin was demonstrated lasting for 8-14 days. Selected preparations were re-tested by a non-occluded method. The results for the ointments were compared with those previously obtained using the corresponding creams.

References


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Citations

Jan 1, 1980·Archives of Dermatological Research·R Wrench
Sep 1, 1978·International Journal of Dermatology·M H Samitz, J E Lewis
Oct 1, 1992·International Journal of Dermatology·L K Pershing
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Apr 1, 2000·Drug Development and Industrial Pharmacy·G P MartinM B Brown
Jan 1, 1987·Current Medical Research and Opinion·E Young, E A van der Velde
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Apr 24, 2016·The Journal of Investigative Dermatology·Parth PatelKarthik Krishnamurthy
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Feb 3, 2004·Skin Pharmacology and Physiology·M S RobertsY G Anissimov
Jan 1, 1993·The British Journal of Dermatology·A Ahluwalia, R J Flower

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