PMID: 1164596Jul 1, 1975

Comparative bioassay of prostaglandin E2 and its three pulmonary metabolites

British Journal of Pharmacology
D J Crutchley, P J Piper

Abstract

The relative potencies of prostaglandin E2 and its metabolites 15-keto PGE2, 13,14-dihydro-15-keto-PGE2 and 13,14,dihydro-PGE2 were investigated on isolated smooth muscle preparations. These were rat stomach strip, colon and uterus, chick rectum, guinea-pig ileum, trachea and pulmonary artery and rabbit aorta and pulmonary artery. 15-keto PGE2 was equiactive or 1-1.8 times more potent than prostaglandin E2 in relaxing guinea-pig trachea but otherwise the three metabolites were less active than prostaglandin E2 on all preparations.

References

Jul 1, 1976·Agents and Actions·E Anggard, E Oliw
Jul 1, 1976·Agents and Actions·P J Piper
Mar 1, 1985·Agents and Actions·W P Kingston, M W Greaves
Oct 1, 1976·Prostaglandins·H S Hansen
Aug 1, 1977·Prostaglandins·H W SeyberthJ A Oates
Jan 1, 1977·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·P J Piper
Jul 1, 1979·Clinical and Experimental Pharmacology & Physiology·A L Boura, R D Murphy
Dec 1, 1977·British Journal of Pharmacology·J R Hoult, P K Moore
Nov 1, 1977·Postgraduate Medical Journal·P J Piper
Apr 15, 1978·Klinische Wochenschrift·H W Seyberth
Jul 1, 1976·British Journal of Pharmacology·M E Chieruttini, C S Franklin

Citations

Feb 14, 1970·Nature·P J PiperJ H Wyllie
Apr 1, 1966·Acta Physiologica Scandinavica·E Anggard
Feb 1, 1964·British Journal of Pharmacology and Chemotherapy·E W HORTON, C J THOMPSON

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