Comparative bioavailability of aspirin and paracetamol following single dose administration of soluble and plain tablets

Current Medical Research and Opinion
N MuirJ Sykes

Abstract

In this study, the bioavailability of aspirin and paracetamol was compared in plain and soluble combination formulations in fasting, healthy volunteers. Blood samples were taken and Cmax, Tmax and AUC measured at various times following administration of single doses of the two formulations in 12 subjects. The rapidity of uptake of aspirin following administration of a soluble formulation suggests significant absorption from the stomach. There was no significant difference in the pharmacokinetic parameters of paracetamol derived from a soluble or plain formulation. A comparison of the uptake of aspirin from the soluble aspirin formulation with paracetamol from either plain or soluble tablets showed that aspirin entered the plasma and achieved peak levels significantly more quickly. However, the half life of paracetamol was significantly longer than that of aspirin. These findings suggest that onset of analgesia should be more rapid following dosing with soluble aspirin, a conclusion supported by comparative efficacy studies conducted with differing formulations of aspirin.

References

Jul 1, 1979·British Journal of Clinical Pharmacology·M Hills, P Armitage
Oct 1, 1977·Journal of Pharmaceutical Sciences·L W WhitehouseB H Thomas
Oct 1, 1988·British Journal of Clinical Pharmacology·I S HollandR C Hoare
Dec 1, 1972·American Journal of Diseases of Children·L TarlinJ J Alpert
Aug 1, 1983·Journal of Pharmaceutical Sciences·B AmeerL Shargel
Jun 1, 1980·European Journal of Clinical Pharmacology·P SeidemanA Labross

❮ Previous
Next ❯

Citations

Oct 12, 2012·Applied Microbiology and Biotechnology·Shijin WuJianmeng Chen
May 2, 2013·Journal of Hazardous Materials·Jong-Kwon ImYeomin Yoon
Dec 14, 2006·Clinical Drug Investigation·Mahmoud Mohamed IssaNaser Said El-Abadla
Sep 16, 2014·Expert Opinion on Drug Metabolism & Toxicology·Marzia LecchiPaolo Martelletti
Jan 1, 1997·Current Medical Research and Opinion·N MuirR C Hoare
Jan 10, 2006·Ecotoxicology and Environmental Safety·Patrick K Jjemba
Apr 24, 2016·Water Research·Chuanzhou LiangYingbao Liu
Oct 16, 2012·Chemosphere·Mark Daniel G de LunaMing-Chun Lu
Jul 17, 2016·Journal of Environmental Management·C EscapaM Otero
Nov 4, 2006·Expert Review of Cardiovascular Therapy·Peter ElwoodGareth Morgan
Mar 18, 2016·Environmental Science and Pollution Research International·Fei CaoZhenhu Hu
Mar 10, 2017·Environmental Technology·Karnika Ratanapongleka, Supot Punbut
Sep 20, 2018·Environmental Science and Pollution Research International·Francesca AudinoOrlando Mario Alfano
Dec 3, 2020·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Pyla Jayasree, Neelancherry Remya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Exposure Analysis and Environmental Epidemiology
J A ShoemakerT D Behymer
Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
Marion MartignacFlorence Benoit-Marquié
European Journal of Drug Metabolism and Pharmacokinetics
T NärvänenM Marvola
© 2021 Meta ULC. All rights reserved