Comparative bioenergetic study of neuronal and muscle mitochondria during aging

Free Radical Biology & Medicine
Hong-Zhi LiYidong Bai


Mitochondrial respiratory chain defects have been associated with various diseases and with normal aging, particularly in tissues with high energy demands, including brain and skeletal muscle. Tissue-specific manifestation of mitochondrial DNA (mtDNA) mutations and mitochondrial dysfunction are hallmarks of mitochondrial diseases although the underlying mechanisms are largely unclear. Previously, we and others have established approaches for transferring mtDNA from muscle and synaptosomes of mice at various ages to cell cultures. In this study, we carried out a comprehensive bioenergetic analysis of cells bearing mitochondria derived from young, middle-aged, and old mouse skeletal muscles and synaptosomes. Significant age-associated alterations in oxidative phosphorylation and regulation during aging were observed in cybrids carrying mitochondria from both skeletal muscle and synaptosomes. Our results also revealed that loss of oxidative phosphorylation capacity may occur at various ages in muscle and brain. These findings indicate the existence of a tissue-specific regulatory mechanism for oxidative phosphorylation.


Jan 11, 2000·Molecular and Cellular Biology·Yidong BaiGiuseppe Attardi
Feb 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·H HermekingK W Kinzler
Oct 29, 2000·Experimental Gerontology·Martin D Brand
Jun 19, 2001·Experimental Gerontology·H Van Remmen, A Richardson
Jan 10, 2002·Nature·Karim S EchtayMartin D Brand
Mar 1, 2002·Mechanisms of Ageing and Development·Brian H Anderton
Dec 7, 2002·The Biochemical Journal·Rodrigue RossignolThierry Letellier
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marilena GrecoGiuseppe Attardi
May 6, 2004·Annals of the New York Academy of Sciences·Yidong BaiGiuseppe Attardi
May 28, 2004·Nature·Aleksandra TrifunovicNils-Göran Larsson
Apr 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kevin R ShortK Sreekumaran Nair
May 18, 2005·Biochemical and Biophysical Research Communications·Béatrice ChabiGeorges Stepien
Jun 21, 2005·Annals of the New York Academy of Sciences·Yidong BaiPeiqing Hu
Dec 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aleksandra TrifunovicNils-Göran Larsson
Jul 13, 2006·Ageing Research Reviews·Edward J Lesnefsky, Charles L Hoppel
Oct 9, 2008·Biochimica Et Biophysica Acta·Julio MontoyaEduardo Ruiz-Pesini
Oct 9, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Entela Bua LushajJudd M Aiken
Apr 10, 2009·Current Medicinal Chemistry·Lokendra Kumar SharmaYidong Bai
Dec 22, 2009·Current Aging Science·Paola RossiFulvio Marzatico


Dec 3, 2014·Redox Biology·Heather M WilkinsR H Swerdlow
Aug 27, 2014·Frontiers in Aging Neuroscience·Marta Gonzalez-FreireLuigi Ferrucci
Sep 28, 2013·Biochimica Et Biophysica Acta·R H SwerdlowShaharyar M Khan
Mar 19, 2020·Journal of Clinical Medicine·Riccardo BorzuolaAndrea Macaluso
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Shayne MasonRoan Louw

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