Comparative bioenergetic study of neuronal and muscle mitochondria during aging

Free Radical Biology & Medicine
Hong-Zhi LiYidong Bai

Abstract

Mitochondrial respiratory chain defects have been associated with various diseases and with normal aging, particularly in tissues with high energy demands, including brain and skeletal muscle. Tissue-specific manifestation of mitochondrial DNA (mtDNA) mutations and mitochondrial dysfunction are hallmarks of mitochondrial diseases although the underlying mechanisms are largely unclear. Previously, we and others have established approaches for transferring mtDNA from muscle and synaptosomes of mice at various ages to cell cultures. In this study, we carried out a comprehensive bioenergetic analysis of cells bearing mitochondria derived from young, middle-aged, and old mouse skeletal muscles and synaptosomes. Significant age-associated alterations in oxidative phosphorylation and regulation during aging were observed in cybrids carrying mitochondria from both skeletal muscle and synaptosomes. Our results also revealed that loss of oxidative phosphorylation capacity may occur at various ages in muscle and brain. These findings indicate the existence of a tissue-specific regulatory mechanism for oxidative phosphorylation.

References

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Citations

Dec 3, 2014·Redox Biology·Heather M WilkinsR H Swerdlow
Aug 27, 2014·Frontiers in Aging Neuroscience·Marta Gonzalez-FreireLuigi Ferrucci
Sep 28, 2013·Biochimica Et Biophysica Acta·R H SwerdlowShaharyar M Khan
Mar 19, 2020·Journal of Clinical Medicine·Riccardo BorzuolaAndrea Macaluso
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Shayne MasonRoan Louw

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