Comparative biology of the ubiquitous Na+/H+ exchanger, NHE1: lessons from erythrocytes

Journal of Experimental Zoology. Part A, Comparative Experimental Biology
S F Pedersen, P M Cala

Abstract

By virtue of their electroneutral exchange of intracellular H+ for extracellular Na+, the Na+/H+ exchangers (NHE1-NHE8) play a pivotal role in many physiological processes. This review focuses on the ubiquitous plasma membrane isoform, NHE1. Particular attention is given to the roles and regulation of NHE1 in erythrocytes, in their own right and as model systems, but pertinent findings from non-erythroid cells are also discussed. NHE1 plays a key role in the regulation of cell volume and pH, and consequently in the control of such diverse processes as blood O2/CO2 transport, and cell proliferation, motility, and survival. Disturbances in NHE1 function are involved in important pathological states such as hypoxic cell damage and cancer development. NHE1 has a predicted topology of 12 transmembrane domains, and a hydrophilic C-terminus thought to be the major site for NHE1 regulation. NHE1 is highly conserved throughout the vertebrate phylum, particularly in the transmembrane region and the proximal part of the C-terminus. In non-erythroid, and probably also in erythroid cells, this part of the hydrophilic C-terminus interacts with multiple binding partners important for NHE1 function. Erythrocyte NHE1s from mammalian, amphibian,...Continue Reading

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·F BorgeseR Motais
Jan 1, 1991·Annals of the New York Academy of Sciences·S E AndersonE Murphy
Jun 1, 1990·The Journal of Membrane Biology·M CanessaR L Nagel
Jul 1, 1986·The American Journal of Physiology·M L JenningsP E McAndrew
Apr 1, 1989·The American Journal of Physiology·R MotaisS Thomas
Jul 1, 1987·Journal of Cellular Physiology·N Escobales, A Rivera
Jan 1, 1995·International Review of Cytology·E K Hoffmann, P B Dunham
Feb 1, 1995·The American Journal of Physiology·H GuizouarnR Motais
Jun 1, 1994·The Journal of General Physiology·P M Cala, H M Maldonado
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·F BorgeseR Motais
Sep 1, 1996·Diabetes Care·O GiampietroR Pedrinelli
Jan 1, 1997·Physiological Reviews·S WakabayashiJ Pouyssegur
May 1, 1997·The American Journal of Physiology·H IidaY Shibata
Nov 14, 1997·The Journal of Experimental Zoology·M KaloyianniA Boukla
Mar 26, 1998·Journal of Neuroscience Research·S F PedersenE K Hoffmann
Jun 24, 1998·Pflügers Archiv : European journal of physiology·M BleichR Greger
Aug 26, 1998·The EMBO Journal·T TominagaD L Barber
Mar 10, 1999·The American Journal of Physiology·S N OrlovP Hamet
Apr 13, 1999·The American Journal of Physiology·L H YehB R Alevriadou
May 18, 1999·The American Journal of Physiology·L A McLeanP M Cala
Feb 7, 2001·American Journal of Physiology. Cell Physiology·L A McLeanP M Cala
Jul 13, 2000·The Journal of Cell Biology·O AharonovitzS Grinstein
Oct 29, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S J ReshkinM Tommasino
Sep 8, 2001·American Journal of Physiology. Cell Physiology·H YaoG G Haddad
Oct 24, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S L EdwardsT Toop
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·L K PutneyD L Barber
Feb 5, 2002·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·P KoldkjaerF B Jensen
Mar 27, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S F PedersenJ W Mills
Mar 29, 2002·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·C J BraunerF B Jensen
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Emily C RothsteinPamela A Lucchesi
Jul 26, 2002·The Journal of Biological Chemistry·Xiuju LiLarry Fliegel
Aug 3, 2002·Nature Reviews. Molecular Cell Biology·Anthony BretscherRichard G Fehon
Aug 6, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Mikko Nikinmaa
May 8, 2003·American Journal of Physiology. Cell Physiology·Stine F PedersenPeter M Cala

❮ Previous
Next ❯

Citations

Apr 6, 2006·Pflügers Archiv : European journal of physiology·Stine Falsig Pedersen
Jun 17, 2010·The Journal of Biological Chemistry·Shigeo WakabayashiTakashi Hisamitsu
Oct 24, 2008·Acta Physiologica·I H LambertS F Pedersen
Sep 30, 2010·Acta Physiologica·E K Hoffmann, S F Pedersen
Jan 10, 2013·Haematologica·Thomas B BartnikasMark D Fleming
Mar 25, 2006·The Journal of Physiology·Misa MizumoriYasutada Akiba
Apr 22, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Karina KristensenTobias Wang
Aug 1, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Tatiana I IvanovaGennadii P Gusev
Aug 26, 2006·Cellular Immunology·Paolo De Vito
Mar 2, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Stefania MuzzachiElena Ciani
Nov 6, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Stine Falsig PedersenElse Kay Hoffmann
Dec 20, 2018·The Journal of Biological Chemistry·Suilan ZhengPhilip S Low
Feb 14, 2009·Biogerontology·S Asha DeviM V V Subramanyam
Feb 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S F PedersenP M Cala
Jan 8, 2009·Physiological Reviews·Else K HoffmannStine F Pedersen
Mar 2, 2017·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Pin-Chun Chao, A Grant Butt
Jun 19, 2007·The Journal of Experimental Biology·Karina KristensenTobias Wang
Aug 5, 2006·The Journal of Experimental Biology·Khaled H AhmedGerhard Krumschnabel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.